The anticancer activity of Ashwagandha

Ashwagandha is an ancient herb that has been used in Ayurvedic medicine for centuries.

• ashwagandha reduces cortisol
• inhibits glutamine transporters {wiki}
  
• balances the endocrine system
• decreases total cholesterol
• has anticancer activity
• may help lower prolactin
• reduces ammonia
• caution in hormone-sensitive prostate cancer.{14.7% ▲ Testosterone} Testosterone is regarded as a hormone that promotes prostate cancer, although new research show sometimes T can also slow down prostate cancer, especially in the early stages, with low and stable PSA.
• In vitro studies have shown that root and leaf extracts have cytotoxic properties against lung, colon, central nervous system, and breast cancer cell lines.
• potential to block constitutive autophosphorylation of BRAF {study}
• restoration of wild type p53 function in mutant p53Y220C cells {study}
• withaferin A inactivates GPX4 by increasing the Fe2+ level, and thereby inducing ferroptosis {ref}
• sleep aid: 2 - 3 capsules before bed.
• Ashwagandha may lower blood sugar levels 

A Low Dose Combination of Withaferin A and Caffeic Acid Phenethyl Ester Possesses Anti-Metastatic Potential In Vitro: Molecular Targets and Mechanisms

References

• Widodo, Nashi & Takagi, Yasuomi & Shrestha, Bhupal & Ishii, Tetsuro & Kaul, Sunil & Wadhwa, Renu. (2008). Selective killing of cancer cells by leaf extract of Ashwagandha: Components, activity and pathway analyses. Cancer letters. 262. 37-47. 10.1016/j.canlet.2007.11.037.
• http://withaferina.com/withaferina99.html
• https://www.nutraingredients-usa.com/Article/2017/12/01/Ashwagandha-ginseng-found-to-mimic-off-label-anti-aging-effects-of-two-drugs#
• https://vib.be/nl/nieuws/nieuw-wapen-tegen-chemotherapie-resistente-kankercellen-ontdekt