This blog post is about the treatment of glioblastoma, a type of brain cancer. It describes the case of a patient diagnosed in 2002 who, against the odds, has survived for over 20 years.
Last updated July 10,2025
During the following months, he received the standard treatment for this type of tumor: radiation followed by chemotherapy. The cancer came back and continued to grow during the treatment with Temozolomide. His oncologist said further treatment would be useless.
He was fortunate that another neuro-oncologist agreed to take over his care, allowing him to start a new round of chemotherapy: CCNU (lomustine) and Tamoxifen (40mg/day), an antiestrogenic drug. The goal was to extend Jorge's life for a few months.
A new MRI, one month later, showed a slight reduction of the tumor. Jorge continued taking CCNU, Tamoxifen, Melatonin, and Aminocare A10 (Vitamin B-2 10.2 mg, L-Alanine 50.0 mg, L-Arginine 54.0 mg, Glycine 50.0 mg, L-Ornithine 50.0 mg, L-Glutamine Derivative (A10) 350.0 mg, L-Serine 50.0 mg, L-Threonine 50.0 mg, L-Valine 50.0 mg per serving). He stayed on a sugar-free, meat-restricted diet. He was able to complete the 6-month CCNU treatment without any noticeable side effects.
By January 2004, the tumor was virtually gone, and what was left was scar tissue. Now,17 22 years after his cancer diagnosis, he's enjoying his pension. He still takes Tamoxifen, a reduced maintenance dose.
Because Glioblastoma cures are so rare, you're left wondering why the tumor disappeared. Here’s what I learned, and it indicates that each addition to chemotherapy, though one in particular, was instrumental in achieving a positive outcome.
By January 2004, the tumor was virtually gone, and what was left was scar tissue. Now,
Because Glioblastoma cures are so rare, you're left wondering why the tumor disappeared. Here’s what I learned, and it indicates that each addition to chemotherapy, though one in particular, was instrumental in achieving a positive outcome.
CCNU
A phase III trial on the combination of bevacizumab and lomustine versus lomustine (CCNU) in patients with the first progression of glioblastoma resulted in 8.8% of patients in the combination-therapy arm with no progression at 1 year, compared with 1.9% of patients in the lomustine-alone arm. Overall survival did not differ between the two study arms, with a median overall survival of only 8.6 months for the lomustine-alone study group and 9.1 months for the bevacizumab + lomustine study group.
Tamoxifen
In vitro, Tamoxifen is effective at killing glioma cells; however, several studies have not shown any benefit in overall survival. More recently, a study titled "Tamoxifen for Recurrent High-Grade Glioma: A Retrospective Study" evaluated the use of tamoxifen in patients with recurrent high-grade gliomas, including glioblastoma multiforme (GBM). The findings revealed that approximately 80% of patients experienced disease progression while on tamoxifen. However, among those who achieved stable disease or a partial response, the median overall survival (mOS) was notably extended: over 40 weeks for GBM patients and more than 80 weeks for non-GBM patients. Additionally, tamoxifen was well-tolerated, with minimal toxicity reported. These results suggest that while tamoxifen may not prevent disease progression in most cases, it could offer a survival benefit for a subset of patients who respond to the treatment.
Melatonin
The argument for using melatonin as a supplement in the treatment of glioblastoma is gaining increasing support. New studies confirm the anticancer activity and synergy of melatonin with chemotherapy {ref}. Jorge continued taking melatonin, albeit sporadically, for several years.
Antineoplastons/ Phenylbutyrate
Sodium Phenylbutyrate (NaPB) is a drug to treat a genetic disorder called Urea Cycle Disorder. Sodium phenylbutyrate is approximately 22.5% sodium by weight. When this drug is metabolized in the body, it produces byproducts, phenylacetylglutamine (PAG) and phenylacetate, which are the same compounds Dr. Burzynski produces synthetically (antineoplastons A10 and AS2-1).
Jorge's treatment with "antineoplastons" (A10) is biochemically equivalent to treatment with a high dose of Sodium Phenylbutyrate. His response aligns perfectly with the clinical outcome observed in a case report published by the H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL. They reported a complete response in a patient with recurrent, multicentric malignant glioma treated with phenylbutyrate. The patient in this study took 3 daily doses of Phenylbutyrate orally, 18 grams a day. The dosage was reduced after the first month to 9 g per day to minimize the side effects of nausea, headache, and dizziness. The dosage was further reduced to 4.5 g per day due to a mild elevation in serum transaminase levels. The patient was followed with serial MRI scans every two months, showing a steady decrease in the tumor size. After nine months of phenylbutyrate, the tumor regressed completely. This dosage is nearly identical to the amount of phenylacetylglutamine we used. For each gram of sodium phenylbutyrate administered, it is estimated that between 0.12 and 0.15 grams of phenylacetylglutamine nitrogen are produced. 18 caps of A10 contain 3,15 grams of a 4:1 mixture of phenylacetylglutamine and phenylacetylisoglutamine, or 2,52 grams of phenylacetylglutamine. You'd have to take 16,5 to 21 grams of sodium phenylbutyrate to get that amount of phenylacetylglutamine, on average 18.75 grams.
In 2016, a study found that Phenylbutyrate suppresses the proliferation of glioblastoma LN-229 cell line.
Phenylbutyrate is an HDAC inhibitor, a chemical compound that may block tumor cell proliferation.
Probably just as important, oral phenylbutyrate can be used as a “glutamine trap” to create a model of glutamine/ammonia depletion {study}.
Note that Burzinsky is currently prohibited from selling antineoplastons. Although Aminocare A10 is still available, the formula has changed and no longer contains antineoplastons.
SEF Chemo®
Dr. Ken Matsumura, a physician and researcher at the Berkeley Institute International, developed Side-Effect-Free Chemotherapy (SEF Chemo®) {ref} to enhance cancer treatment efficacy while minimizing adverse effects. One of the combinations they used is carboplatin + sodium phenylbutyrate (NaPB). He states they have found the most success with this combination.{ref}
Jorge's last MRI was in November 2023: no cancer. I can provide an MRI upon request (contact me in the comment section below).
Jorge's Case Revisited by AI (2025)
Jorge's regimen (CCNU + NaPB-equivalent A10 + Melatonin + Tamoxifen) and Matsumura's "SEF Chemo" share a core principle: NaPB/PAG dramatically enhances DNA-damaging chemo by exploiting metabolic/epigenetic vulnerabilities. Jorge's outcome wasn't just luck; it was a prototype of this approach. The regimen simultaneously:
→ Attacks DNA integrity (chemo).
→ Reverses epigenetic silencing (NaPB).
→ Sensitizes cancer cells to chemo (NaPB/melatonin/Tamoxifen).
→ Starves tumors of glutamine (NaPB).
→ Protects healthy tissue (NaPB/melatonin).
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Synergistic combinations of natural compounds and drug repurposingFor information purposes only, nothing I write is medical advice.
Strategy - an integrative approach to glioblastoma management: example of a multi-layered approach using coactive combinations of natural substances and drug repurposing.
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click to enlarge the diagram
Synergistic combinations of natural compounds and drug repurposing
For information purposes only, nothing I write is medical advice.
Strategy - an integrative approach to glioblastoma management: example of a multi-layered approach using coactive combinations of natural substances and drug repurposing.
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click to enlarge the diagram |
Thanks for writing this important report!
ReplyDeleteDo you have an opinion on what dose of sodium phenylbutyrat would be sufficient? 18 grams / day would be ~$1500 / month, which is a bit out of reach for me.
THANK UOU
ReplyDeleteHere's another source for phenylbutyrate: https://www.purepba.com/
ReplyDeleteFor each gram of sodium phenylbutyrate administered, it is estimated that between 0.12 to 0.15 grams of phenylacetylglutamine nitrogen are produced.
ReplyDeleteHello Johan - You seem to have produced a remarkable trove of information. I have just come across your work and will have to spend considerable time to digest everything. I was quickly looking, without success, to see if you had discussed vorasidenib anywhere. I was hoping you had some opinions there given your close history to brain cancer. Looking forward to catching up on everything you have done here. Many thanks for such tremendous effort!
ReplyDeleteHi Steve, no I haven't. I write mainly about natural products and repurposed drugs. IDH mutations induce hypoxia-like conditions and Vorasidenib is effective at inhibiting mutant IDH1 and IDH2 enzymes. Combining this drug with HIF-1α inhibitors may improve its anticancer effects.
ReplyDelete