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| Aminocare A10 |
New Aminocare A10 formula (does not contain antineoplastons):
INGREDIENTS Amount per Serving % Daily Value
Vitamin B2 10 mg 600
Royal Jelly 3:1 376 mg **
Green Tea Extract 264 ml **
Pomegranate extract 188 mg **
L- Arginine 102 mg **
L- Threonine 94 mg **
L- Alanine 94 mg **
L - Valine 94 mg **
Lycopene 38 mg **
** Daily Value not established.
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Old Formula Aminocare A10 (discontinued because of a legal restriction to sell L-Glutamine Derivative A10 outside Texas, USA.)
INGREDIENTS Amount per Serving % Daily Value
Vitamin B-2 10.2 mg 600
L-Alanine 50.0 mg *
L-Arginine 54.0 mg *
Glycine 50.0 mg *
L-Ornithine 50.0 mg *
L-Glutamine Derivative (A10) 350.0 mg *(mixture of phenylacetylglutamine and phenylacetylisoglutamine in a ratio of 4:1)
L-Serine 50.0 mg *
L-Threonine 50.0 mg *
L-Valine 50.0 mg *
Total Weight 714.2 mg
* Daily value not established
Note: Taking L-glutamine doesn't result in the formation of the A10 molecules (phenylacetylglutamine and phenylacetylisoglutamine). The combination, or conjugation, of phenylacetate and glutamine, makes phenylacetylglutamine. Taking oral L-glutamine provides the body of extra glutamine but it's not converted and/or conjugated into different molecules with new functions.
Glycine
“In the context of the excitatory actions of estrogen and the inhibitory action of glycine, it would be reasonable to think of glycine as one of the antiestrogenic substances. “
“A generous supply of glycine/gelatin, against a balanced background of amino acids, has a great variety of antistress actions. Glycine is recognized as an “inhibitory” neurotransmitter and promotes natural sleep. Used as a supplement, it has helped to promote recovery from strokes and seizures and to improve learning and memory. But in every cell type, it apparently has the same kind of quieting, protective antistress action. The range of injuries produced by an excess of tryptophan and serotonin seems to be prevented or corrected by a generous supply of glycine. Fibrosis, free radical damage, inflammation, cell death from ATP depletion or calcium overload, mitochondrial damage, diabetes, etc., can be prevented or alleviated by glycine.” - Ray Peat, Ph.D. (1936-2022)
Amino acids involved in the urea cycle
L-Arginine: a substrate for the enzyme arginase and is converted to ornithine and urea. Arginase catalyzes the reaction of arginine and water to form ornithine and urea, which is then excreted in the urine.
L-Threonine: a substrate for the enzyme threonine aldolase, which catalyzes the reaction of threonine and water to form glycine and acetyl-CoA. The acetyl-CoA is then used to form citrulline, an intermediate in the urea cycle.
L-Alanine: a substrate for the enzyme alanine aminotransferase, which catalyzes the reaction of alanine and α-ketoglutarate to form pyruvate and glutamate. The pyruvate is then converted to oxaloacetate, an intermediate in the urea cycle. Alanine plays an important role in transferring ammonia from the periphery to the liver.
Alanine supplementation exploits glutamine dependency induced by SMARCA4/2-loss
https://www.nature.com/articles/s41467-023-38594-3"supplementation of alanine restricts glutamine uptake through competition and selectively induces death in SMARCA4/2-deficient cancer cells."
L-Valine: a substrate for the enzyme valine aminotransferase, which catalyzes the reaction of valine and α-ketoglutarate to form α-keto-isocaproate and glutamate. The α-keto-isocaproate is then converted to isocaproate, which is an intermediate in the urea cycle.
L-Serine: a substrate for the enzyme serine dehydratase, which catalyzes the reaction of serine and water to form pyruvate and ammonia. The pyruvate is then converted to oxaloacetate, an intermediate in the urea cycle.
L-Ornithine: a substrate for the enzyme ornithine transcarbamylase, which catalyzes the reaction of ornithine and carbamoyl phosphate to form citrulline. Citrulline is then further converted to arginine, which is used to form urea.
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Thanks for explaining the differences in the old and new formulas. I assume the old formula with the seven different amino acids may be considered as the more desirable. I'm wondering if Sodium Phenylbutyrat (4-PBA) Powder will take the place of both the phenylacetylglutamine and phenylacetylisoglutamine and provide the antineoplastons that were in the old formula. Thank you.
ReplyDeleteIt will provide phenylacetylglutamine but not phenylacetylisoglutamine Roy. But phenylacetylglutamine is the most important compound of both. There's no prodrug that I know of that will produce phenylacetylisoglutamine.
ReplyDeleteThanks Johan. I'm wondering if the higher doses of the four amino acids in the new formula has any merit, indeed I'm wondering if there might be benefit if all seven amino acids in the old formula are taken at higher than the listed servings.
ReplyDeletePeople would take 10 or more servings of the old formula, there wasn't anything in it that could cause toxicity to the liver. The new formula has green tea extract and although egcg has been found safe up to 800mg a day, a higher dose needs to be monitored carefully: https://www.nutraingredients.com/Article/2018/04/19/EGCG-warning-EFSA-safety-assessment-suggests-green-tea-supplements-should-come-with-warning# The new formula is a totally different product.
ReplyDeleteThanks for the warning on EGCG Johan. Regarding the original A10 formula, phenylacetylglutamine and phenylacetylisoglutamine were included in a ratio of 4:1. Given that phenylacetylisoglutamine is apparantly not available I'm wondering if anybody making an attempt at recreating this original formula may gain benefit in replacing the phenylacetylisoglutamine with L-glutamine. Thank you
ReplyDeletePhenylacetylisoglutamine is a phenylacetate metabolite formed mainly in the liver and can be formed after phenylacetate is conjugated with glutamine. So in theory it may be that admistering L-glutamine with PB would produce Phenylacetylisoglutamine. But I'm really guessing Roy.
ReplyDeleteRoy, I asked ChatGTP about my comment above and this was the response: "Yes, in theory, administering L-glutamine alongside phenylbutyrate could increase the production of phenylacetylisoglutamine (PAIG). However, the rate and efficiency of PAIG formation would depend on several factors, including the body's capacity to metabolize phenylbutyrate into phenylacetate and the liver's availability of enzymes responsible for this conjugation. In practice, though, the approach of combining L-glutamine with phenylbutyrate has not been widely explored or documented, so any enhanced effect on PAIG levels would likely require empirical verification."
ReplyDeleteThanks Johan. It would seem anybody attempting to recreate the original A10 4:1 ratio and perhaps hoping for an outcome reflected in some patients who seem to have had success with original A10 may have nothing to lose by including L-glutamine in order to somewhat more faithfully replicate the original L-glutamine derivative 4:1 ratio. Most interesting.
ReplyDeleteI agree Roy.
ReplyDeleteFor each gram of sodium phenylbutyrate administered, it is estimated that between 0.12 to 0.15 grams of phenylacetylglutamine nitrogen are produced.
ReplyDeletehttps://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=639f5c7e-9f6d-47fb-a417-2be076176a78&type=display