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| Aminocare A10 |
New Aminocare A10 formula (does not contain antineoplastons):
INGREDIENTS Amount per Serving % Daily Value
Vitamin B2 10 mg 600
Royal Jelly 3:1 376 mg **
Green Tea Extract 264 ml **
Pomegranate extract 188 mg **
L- Arginine 102 mg **
L- Threonine 94 mg **
L- Alanine 94 mg **
L - Valine 94 mg **
Lycopene 38 mg **
** Daily Value not established.
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Old Formula Aminocare A10 (discontinued)
INGREDIENTS Amount per Serving % Daily Value
Vitamin B-2 10.2 mg 600
L-Alanine 50.0 mg *
L-Arginine 54.0 mg *
Glycine 50.0 mg *
L-Ornithine 50.0 mg *
L-Glutamine Derivative (A10) 350.0 mg * (mixture of phenylacetylglutamine and phenylacetylisoglutamine in the ratio of 4 to 1)
L-Serine 50.0 mg *
L-Threonine 50.0 mg *
L-Valine 50.0 mg *
Total Weight 714.2 mg
* Daily value not established
“In the context of the excitatory actions of estrogen and the inhibitory action of glycine, it would be reasonable to think of glycine as one of the antiestrogenic substances. “
“A generous supply of glycine/gelatin, against a balanced background of amino acids, has a great variety of antistress actions. Glycine is recognized as an “inhibitory” neurotransmitter, and promotes natural sleep. Used as a supplement, it has helped to promote recovery from strokes and seizures, and to improve learning and memory. But in every type of cell, it apparently has the same kind of quieting, protective antistress action. The range of injuries produced by an excess of tryptophan and serotonin seems to be prevented or corrected by a generous supply of glycine. Fibrosis, free radical damage, inflammation, cell death from ATP depletion or calcium overload, mitochondrial damage, diabetes, etc., can be prevented or alleviated by glycine.” - Ray Peat, Ph.D. (1936-2022)
Amino acids involved in the urea cycle
L-Arginine: a substrate for the enzyme arginase and is converted to ornithine and urea. Arginase catalyzes the reaction of arginine and water to form ornithine and urea, which is then excreted in the urine.
L-Threonine: a substrate for the enzyme threonine aldolase, which catalyzes the reaction of threonine and water to form glycine and acetyl-CoA. The acetyl-CoA is then used to form citrulline, which is an intermediate in the urea cycle.
L-Alanine: a substrate for the enzyme alanine aminotransferase, which catalyzes the reaction of alanine and α-ketoglutarate to form pyruvate and glutamate. The pyruvate is then converted to oxaloacetate, which is an intermediate in the urea cycle. Alanine plays an important role in transferring ammonia from the periphery to the liver.
Alanine supplementation exploits glutamine dependency induced by SMARCA4/2-loss
https://www.nature.com/articles/s41467-023-38594-3"supplementation of alanine restricts glutamine uptake through competition and selectively induces death in SMARCA4/2-deficient cancer cells."
L-Valine: a substrate for the enzyme valine aminotransferase, which catalyzes the reaction of valine and α-ketoglutarate to form α-keto-isocaproate and glutamate. The α-keto-isocaproate is then converted to isocaproate, which is an intermediate in the urea cycle.
L-Serine: a substrate for the enzyme serine dehydratase, which catalyzes the reaction of serine and water to form pyruvate and ammonia. The pyruvate is then further converted to oxaloacetate, which is an intermediate in the urea cycle.
L-Ornithine:a substrate for the enzyme ornithine transcarbamylase, which catalyzes the reaction of ornithine and carbamoyl phosphate to form citrulline. Citrulline is then further converted to arginine, which is used to form urea.
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