Thursday, December 8, 2022

Combination of Natural Supplements as Adjunct Cancer Therapy

Natural supplements can be very helpful adjuvant to drug therapies, for example through chemosensitization of tumor cells. Unfortunately, it seems that very often there's little or no follow-through when readily available natural products show great potential in cancer treatment. Here's a list of compounds with potential anticancer effects, and synergistic combinations. These are some of the safest, most effective broad-spectrum anticancer natural substances.
. 
  1. ArtemisininπŸ›ˆ CT FER AA  
    •  HonokiolπŸ›ˆ MT, RMDR  → (orlistat) FAS πŸŸͺπŸ”Ά (aspirin) πŸŸͺπŸ”Ά AMPK (+ 200mg vit. C)
      •  Modified Citrus PectinπŸ›ˆ Ursolic acidπŸ›ˆ FAS  Luteolin CCAA ST3 (ld)
  2.  Curcumin πŸ›ˆ ST3 MT RMDR   Emodin → (celecoxib) πŸŸͺπŸ”ΆCOX-2  Luteolin (ld) ˃
    • → Apigenin πŸ›ˆ CCAA CAI    Salvia miltiorrhiza πŸ›ˆ CCAA Astragalus πŸ›ˆ
    • → Boswellia πŸ›ˆ πŸ”΅
    • → Iodine ↓ πŸ›ˆ
    •  DHA docosahexaenoic acidπŸ›ˆ  ButyrateπŸ›ˆ  Citric acidπŸ›ˆ GI LR Graviola
      •  Melatonin → Andrographis πŸ›ˆ → Berberine MT CT HIF  D-limoneneπŸ›ˆ
          • → Shikonin ICD GI                        Andrographis πŸ›ˆ NFi CCAA
    •  EGCgπŸ›ˆ πŸ‹ → ↓ Quercetin (ld)   Grapeseed extract  AA  Phellinus linteus
      • → Luteolin (ld) → (celecoxib) πŸŸͺπŸ”Ά  
            • →  ↑   Curcumin                     
      •  IP6 & InositolπŸ›ˆ  (+ 200mg Vit. C)   Pterostilbene ˃
      •  Ginger / 6-Shogaol πŸ›ˆ  Licorice T⏷→ Boswellia CCAA
      •   Chlorogenic acid πŸ›ˆ Theobromine πŸ›ˆ AA
      •   Lipoic acidπŸ›ˆ MT, RMDR Hydroxycitrate  (orlistat) πŸŸͺπŸ”Ά ROSI
      • ↓ Milk Thistle πŸ›ˆ  Baicalein HIF AA ST3  Salvia miltiorrhiza πŸ›ˆ AUM▼
    •                  Nigella Sativa / Thymoquinone πŸ›ˆ  AA HIF NFi EmodinπŸ”΅
    • → Vitamin D ☼ πŸ›ˆ    LycopeneπŸ›ˆ AI FAK 
    • → Sulforaphane πŸ›ˆ → Dihydrocaffeic Acid 
    •  Vitamin C πŸ›ˆ 
      • → Vitamin K2→ Phosphatidylcholine
      • Magnesium LR
      • → Juglone CCAA
      • Riboflavin E⏷
      •  Ashwagandha (T⏶    
    • → PiperlongumineπŸ›ˆ FER→ Sanguinarine  Berberine   Caffeine
    •  Galangal  Tulsi  Piper nigrum
      •   BerberineπŸ›ˆ MT CT HIF RMDR
    • → Oligomeric proanthocyanidins
    •  Taurine
    •  AHCC πŸ›ˆ  FucoidanπŸ›ˆ ST3 (+ 200mg vitamin C)
    • → Carnosic acid  Fisetin  Quercetin  Caffeic acid
    • Mistletoe AA πŸ”΅ Chaga πŸ›ˆ  Rosmarinic acid πŸ›ˆ RMDR EGFR CAI  Cassia cinnamon
      To improve absorption and bioavailability of fat-soluble supplements take with some fat e.g. ghee butter or coconut oil. The optimal dosing of the compounds mentioned in this blog is not known and would depend on the type of cancer and the individual patient's response to the treatment. Please check the information πŸ›ˆ on each compound for suggested dosing and more.

      It may be a good idea to take anticancer supplements right before sleep at night and to include a time during the night in your supplementation schedule e.g. 3AM "study suggests that nighttime is the right time for cancer to grow and spread in the body and that administering certain treatments in time with the body's day-night cycle could boost their efficiency"{ref}. 

      Synergistic natural compounds for cancer treatment

      A natural compound may exhibit anticancer activity but at concentrations that are too high to get any significant benefit (in vitro concentrations not achievable in vivo). However, if synergies exist those same substances may become noticeably effective at lower concentrations. Such combinations can also be used to overcome drug resistance or to sensitize cancer cells to therapeutic agents. 

      multi-layered approach using coactive combinations of natural substances applied in specific sequences may be a very powerful anti-cancer strategy

       anticancer synergy with Artemisinin
       anticancer synergy with HDACi
       possible additive or synergistic antineoplastic effect
      possibly synergistic
      likely to be a good antineoplastic combination  sequential
        the combination may offer hepatoprotective effects
       attenuates DOX-induced kidney injury
      (ld)  low dose
        antagonism
      ˃   anticancer synergy, continue with the first compound on the next line.

      (....) OTC drugs: I've included a few non-oncology drugs with the potential for enhanced anti-cancer action if used in combination with specific supplements. Repurposing non-oncology drugs is an attractive approach to improving cancer therapy.

      πŸ”Ά Be aware of drug interactions.
      πŸŸͺ  Drug Repurposing


      Potential Anticancer Mechanism

      • ICD Immunogenic cell death
      • GI inhibitor of glycolysis
      • CT cytotoxic
      • RMDR reversing multidrug resistance /  sensitization
      • MT multiple targets
      • CCAA cell cycle arrest and apoptosis
      • FAS fatty acid synthase inhibition
      • AA anti-angiogenic
      • EGFR epidermal growth factor receptor Inhibition
      • LR lactate reduction potential
      • FER ferroptosis
      • AMPK ampk activator
      • COX-2 cox-2 inhibitor
      • AI anti-inflammatory
      • FAK focal adhesion kinase downregulation
      • SERM selective estrogen receptor modulator
      • CAI carbonic anhydrase inhibitor
      • HIF hypoxia-inducible factor inhibition  drug resistance 
      • AUM ▼▲autophagy modulation
      • NO Nitric Oxide
      • ROSI reducing oxidative stress and inflammation
      • NFi NF-ΞΊΞ² inhibition
      • ST3 STAT3 inhibition


      Aerobic activity improves outcomesAt least 20 studies of people with breast, colorectal, prostate, and ovarian cancer have suggested that physically active cancer survivors have a lower risk of cancer recurrence and improved survival compared with those who are inactive.

      12 Dietary Strategies to put the brakes on cancer growth













      Cautions regarding the combination of supplements and medication


      Read this first: Warnings, Terms of Use & Disclaimer

      CAUTION Don't exceed the maximum suggested dosagesstart with the lowest possible dose and gradually increase if no side effect is observed.

      If you take medications always check if the supplement(s) can be combined with those drugs, especially with chemotherapy, diabetes medications, anticoagulant and antiplatelet medications (including aspirin), benzodiazepines, etc. Ask a 'Drug Interaction Specialist' Online.

      Stop taking supplements a week before surgery, or consult with your surgeon.

      To combine various supplements add one at a time, start with the lowest possible dose, and gradually increase if no side effect is observed.

      To discontinue a supplement taper off by cutting to a half dose for a week before stopping.

      Dosage, but also time is crucial to achieving a therapeutic effect.

      Supplements should only be taken under the supervision of a healthcare provider. Supplements or herbal preparations shouldn't be used in combination with chemotherapy, radiotherapy, immunotherapy, or any other cancer treatment unless the safety and efficacy of such combinations are established. It's especially important to make sure anything you add to the standard treatment will further improve the efficacy of that treatment, hence the importance of discussing any addition of supplements or dietary interventions during active cancer treatment with the oncologist.

      Synergistic effects of medicinal plants, herbs and fruits

      A partial list of studies and reviews:

      1. A randomized study of chemotherapy versus biochemotherapy with chemotherapy plus Aloe arborescens in patients with metastatic cancer
      2. From ancient herb to modern drug: Artemisia annua and artemisinin for cancer therapy.
      3. Methods for the treatment of cancer using piperlongumine and piperlongumine analogs
      4. The central role of citrate in the metabolism of cancer cells. "citrate has demonstrated anti-cancer properties when administered in excess, sensitizing cancer cells to chemotherapy."
      5. Turkey Tail and Polysaccharide-K
      6. Red (Panax) ginseng and cancer treatment.
      7. Absorption, metabolism, anti-cancer effect and molecular targets of epigallocatechin gallate (EGCG): An updated review.
      8. Activation of tumor suppressor LKB1 by honokiol abrogates cancer stem-like phenotype in breast cancer via inhibition of oncogenic Stat3.
      9. Curcumin decreases Warburg effect in cancer cells by down-regulating pyruvate kinase M2 via mTOR-HIF1Ξ± inhibition
      10. Berberine Enhances Chemosensitivity and Induces Apoptosis Through Dose-orchestrated AMPK Signaling in Breast Cancer
      11. Curcumin And Berberine – Offers New Hope In The Treatment Of Breast And Other Cancers?
      12. Anti-cancer effects of Gynostemma pentaphyllum (Thunb.) Makino (Jiaogulan)
      13. Withaferin A (WFA) inhibits tumor growth and metastasis by targeting ovarian cancer stem cells
      14. Therapeutic Interventions Using Ursolic Acid for Cancer Treatment
      15. Melatonin for the prevention and treatment of cancer
      16. Recent advances in the anti-cancer properties of Nigella sativa, a widely used food additive
      17. Phycocyanin: A Potential Drug for Cancer Treatment
      18. Pyrroloquinoline quinone induces chondrosarcoma cell apoptosis by increasing intracellular reactive oxygen species
      19. Oleanolic Acid Alters Multiple Cell Signaling Pathways: Implication in Cancer Prevention and Therapy
      20. Molecular Iodine Induces Caspase-independent Apoptosis in Human Breast Carcinoma Cells Involving the Mitochondria-mediated Pathway
      21. Brown Seaweed Fucoidan Inhibits Cancer Progression by Dual Regulation of mir-29c/ADAM12 and miR-17-5p/PTEN Axes in Human Breast Cancer Cells
      22. D-limonene rich volatile oil from blood oranges inhibits angiogenesis, metastasis and cell death in human colon cancer cells
      23. A novel therapeutic anticancer property of raw garlic extract via injection but not ingestion
      24. Nature curing cancer – review on structural modification studies with natural active compounds having anti-tumor efficiency
      25. Clinical Response of Metastatic Breast Cancer to Multi-targeted Therapeutic Approach: A Single Case Report
      26. Effects of supplements on medicines
      27. How does turmeric/curcumin interact with coffee/caffeine?
      28. Microalgae in modern cancer therapy: Current knowledge
      29. Role of Magnesium in Vitamin D Activation and Function
      30. Vegetables, fruit, and colon cancer in the Iowa Women's Health Study
      31. Tumor Angiogenesis as a Target for Dietary Cancer Prevention
      32. Short chain fatty acids enriched fermentation metabolites of soluble dietary fibre from Musa paradisiaca drives HT29 colon cancer cells to apoptosis
      33. Natural Products and Synthetic Analogs as a Source of Antitumor Drugs
      34. Ursolic Acid—A Pentacyclic Triterpenoid with aWide Spectrum of Pharmacological Activities
      35. Plants Against Cancer: A Review on Natural Phytochemicals in Preventing and Treating Cancers and Their Druggability
      36. Salvia miltiorrhiza: Chemical and pharmacological review of a medicinal plant
      37. Phytochemicals of garlic: Promising candidates for cancer therapy
      38. Selenium a Potential Treatment for Cancer Metastasis
      39. Phenylbutyrate-induced glutamine depletion in humans: effect on leucine metabolism.
      40. Getting the Balance Right – Vitamin D Co-Factors
      41. Cancer Cells Upregulate NRF2 Signaling to Adapt to Autophagy Inhibition
      42. Autophagy supplies the amino acids necessary for driving mitochondrial OXPHOS in glycolysis-suppressed cells
      43. Synergistic Interactions in Natural Products and Medication
      44. Curcumin Nicotinate Selectively Induces Cancer Cell Apoptosis and Cycle Arrest through a P53-Mediated Mechanism
      45. Retrolective Studies on the Survival of Cancer Patients Treated With Mistletoe Extracts: A Meta-analysis
      46. Upon glycolytic suppression in multiple types of tumor cells, intracellular energy metabolism is reprogrammed toward mitochondrial OXPHOS in an autophagy-dependent manner to ensure cellular survival.
      47. Role of Plants in Stage IV Cancer
      48. Using the Heat-Shock Response To Discover Anticancer Compounds that Target Protein Homeostasis "Surprisingly, many of the strongly active compounds identified were natural products representing five diverse chemical classes (limonoids, curvularins, withanolides, celastraloids, and colletofragarones)"
      49. Neem components as potential agents for cancer prevention and treatment
      50. Anticancer and Cytotoxic Potential of Turmeric (Curcuma longa), Neem (Azadirachta indica), Tulasi (Ocimum sanctum) and Ginger (Zingiber officinale) Extracts on HeLa cell line
      51. Curcumin-Artesunate Based Polymeric Nanoparticle; Antiplasmodial and Toxicological Evaluation in Murine Model
      52. https://www.degruyter.com/view/journals/bmc/4/3/article-p287.xml?language=en
      53. Dying Cells Have Cellular 'Death Code'
      54. Peptides & Proteins
      55. Host defense peptides and peptidomimetics as new weapons for cancer treatment
      56. Synthetic and natural iron chelators: therapeutic potential and clinical use
      57. Natural Compound Histone Deacetylase Inhibitors (HDACi): Synergy with Inflammatory Signaling Pathway Modulators and Clinical Applications in Cancer
      58. Research Strategies in the Study of the Pro-Oxidant Nature of Polyphenol Nutraceuticals
      59. Inhibitors of DNA Methyltransferases From Natural Sources: A Computational Perspective
      60. Pathways in cancer - Homo sapiens (human)
      61. Metabilc Pathway
      62. The TNF Paradox in Cancer Progression and Immunotherapy
      63. Potential risks associated with traditional herbal medicine use in cancer care
      64. Lysine-carnitine conversion in normal and undernourished adult men-suggestion of a nonpeptidyl pathway
      65. Why the tumor cell metabolism is not that abnormal
      66. Understanding the synergy of cancer growth to advance care
      67. Niacin ameliorates oxidative stress, inflammation, proteinuria, and hypertension in rats with chronic renal failure
      68. The reverse Warburg effect is likely to be an Achilles' heel of cancer that can be exploited for cancer therapy
      69. The Effect of Zinc and Lysine Supplementation on Infection Rate and CD4 Count
      70. Raging the War Against Inflammation With Natural Products
      71. Ascorbic acid co-administration with artemisinin-based combination therapies in falciparum malaria
      72. Natural products as potent inhibitors of hypoxia-inducible factor-1Ξ± in cancer therapy
      73. HIF1A Employs CDK8-Mediator to Stimulate RNAPII Elongation in Response to Hypoxia
      74. A comparison of resveratrol and other polyphenolic compounds on Notch activation and endothelial cell activity
      75. Low-dose mistletoe lectin-I reduces melanoma growth and spread in a scid mouse xenograft model
      76. Is Curcumin the Answer to Future Chemotherapy Cocktail?
      77. Understanding the Role of Autophagy in Cancer Formation and Progression Is a Real Opportunity to Treat and Cure Human Cancers
      78. Natural Compounds and Autophagy Modulation
      79. Flavonoids as inhibitors of human neutrophil elastase
      80. Effect of luteolin and apigenin on rosmarinic acid bioavailability in Caco-2 cell monolayers
      81. The Synergistic Cooperation between TGF-Ξ² and Hypoxia in Cancer and Fibrosis
      82. Synergistic enhancement of anticancer effects on numerous human cancer cell lines treated with the combination of EGCG, other green tea catechins, and anticancer compounds
      83. Immune Checkpoint PD-1/PD-L1 CTLA-4/CD80 are Blocked by Rhus verniciflua Stokes and its Active Compounds
      84. Dietary quercetin potentiates the antiproliferative effect of interferon-Ξ± in hepatocellular carcinoma cells through activation of JAK/STAT pathway signaling by inhibition of SHP2 phosphatase
      85. Magnesium is essential for the immune system, including in the fight against cancer
      86. Synthetic Pathways and the Therapeutic Potential of Quercetin and Curcumin


      Sunday, August 14, 2022

      Alternative and Integrative Cancer Treatment Strategies

      The following articles are some of the main strategies discussed by Daniel Stanciu Ph.D. on his blog.

      Shutting Down the Power House of Cancer

      https://www.cancertreatmentsresearch.com/shutting-down-the-power-house-of-cancer-a-strategy-to-

      fight-cancer/


      Modulating the Yin and Yang Energy of Cells to Fight Cancer: Pro-Oxidant Strategy

      https://www.cancertreatmentsresearch.com/modulating-the-yin-and-yang-energy-of-cells-to-fight-cancer-pro-oxidant-strategy/


      pH in Cancer & Tumor Acidification: A Top Treatment Strategy

      https://www.cancertreatmentsresearch.com/ph-cancer-a-top-treatment-strategy/


      Anti-Cholesterol Strategy to Fight Cancer

      https://www.cancertreatmentsresearch.com/reduce-cholesterol-in-cancer-cells-to-fight-cancer/


      Releasing the Brakes of Cellular Division to Fight Cancer

      https://www.cancertreatmentsresearch.com/releasing-the-brakes-of-cellular-division-to-fight-cancer/


      Tumors Talk in a Language That Looks Like Viruses- Muting Them Could Prevent Progression & Metastasis

      https://www.cancertreatmentsresearch.com/exosomes-in-cancer/

      Wednesday, July 20, 2022

      5-Day Protocol



      This "protocol" is an attempt to address some of the points raised in this post (Theory of Cancer - limit the consequences of aerobic fermentation + help restore the oxygen and carbon dioxide deprivation).

      • 500 mg Vitamin C  BID (*) πŸ›ˆ and 400 mg Magnesium (malate) BID for 5 consecutive days, 1 hour after lunch and dinner. 
      • 2 grams of Bicarbonate πŸ›ˆ BID and 400 mg Magnesium (malate) BID (*) πŸ›ˆ for 5 consecutive days, 1 hour after lunch and dinner.
      • Shiitake, Melatonin 2-3mg πŸ›ˆ  Niacinamide 20-40mg, and 1 Aloe Vera (barbadensis) softgel for 5 consecutive days.(Niacinamide and Melatonin 10 to 20 minutes before bed)
      • Nigella Sativa πŸ›ˆ , Curcumin πŸ›ˆ , and Rosemary πŸ›ˆ for 5 consecutive days.
      • 400mg Berberine, Trace Mineral drops, and L-Ornithine-L- Aspartate (LOLA) each day for 5 consecutive days.
      • 100 mcg of Methylene Blue or 50 mcg LeucoMethylene Blue/DHA (*) πŸ›ˆ and 100 mg lipoic acid πŸ›ˆ for 5 consecutive days, in the evening. 
      • 5 days REST. Repeat.


      Reasoning

      Melatonin  (Hypoxia-inducible factor-1, enhance apoptosis, reversing Warburg)

      Niacinamide (Hypoxia-inducible factor-1, HDACi)

      Aloe Vera, synergistic with Melatonin

      Vitamin C (Hypoxia-inducible factor-1)

      Bicarbonate (Increase CO2, reduce lactic acid)

      Magnesium works in synergy with vitamin C and bicarbonate.

      Methylene Blue (Increase O2 delivery to tissues)

      Lipoic acid (reduce lactic acid, synergistic with MB)

      Shiitake (anti-cancer, beta-glucan, copper)

      Curcumin (anti-inflammatory, anti-cancer)

      Nigella Sativa (synergistic with Curcumin, Hypoxia-inducible factor-1)

      Rosemary (synergy with Curcumin, carbonic anhydrase inhibition)

      L-Ornithine-L- Aspartate or, as a substitute, Ceylon Cinnamon (ammonia ≫ lactate reduction, improves liver function)


      (*) Hypoxia-inducible factor-1 inhibition: HIF-1Ξ± stimulates glycolytic gene expression.


      Consult with a healthcare professional before starting any diet or supplement.


      References

      The role of hypoxia-inducible factors in tumor angiogenesis and cell metabolism

      https://www.sciencedirect.com/science/article/pii/S2352304216300721


      Ascorbic acid and ascorbate-2-phosphate decrease HIF activity

      and malignant properties of human melanoma cells

      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636772/

      "supplementation with either AA, or its oxidation-resistant analog

      A2P, effectively reduces HIF-1Ξ± protein"


      Restoring physiological levels of ascorbate slows tumor growth and

      moderates HIF-1 pathway activity in Gulo−/− mice

      https://onlinelibrary.wiley.com/doi/10.1002/cam4.349

      "Levels of HIF-1Ξ± protein in tumors decreased as dietary ascorbate

      supplementation increased for both tumor models"


      Melatonin effect on hypoxia-inducible factor-1Ξ± and clinical

      response in patients with oral squamous cell carcinoma receiving

      neoadjuvant chemotherapy: A randomized controlled trial

      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8335757/

      "Our study showed a significant decrease in HIF-1Ξ± expression

      in the melatonin group compared to the placebo group"


      Melatonin inhibits lung cancer development by reversing the Warburg effect

      via stimulating the SIRT3/PDH axis

      https://pubmed.ncbi.nlm.nih.gov/34214200/

      "the underlying mechanism of MLT was related to reprogramming cancer

      cell metabolism, accompanied by a shift from cytosolic aerobic glycolysis

      to oxidative phosphorylation"


      How Curcumin Targets Inflammatory Mediators in Diabetes:

      Therapeutic Insights and Possible Solutions

      https://www.mdpi.com/1420-3049/27/13/4058/htm


      Alpha-Lipoic acid treatment decreases serum lactate and pyruvate

      concentrations and improves glucose effectiveness in lean and obese

      patients with type 2 diabetes.

      https://pubmed.ncbi.nlm.nih.gov/10333946


      Carnosic acid inhibits the growth of ER-negative human breast cancer cells

      and synergizes with curcumin

      https://pubmed.ncbi.nlm.nih.gov/22828666/

      "Rosemary/carnosic acid, alone or combined with curcumin, may be useful to

      prevent and treat ER-negative breast cancer."


      The interplay between HIF-1 and calcium signaling in cancer

      https://pubmed.ncbi.nlm.nih.gov/29407528/


      The longevity top 3: rosmarinic acid, pomegranate, and curcumin.

      https://www.ergo-log.com/longevity-rosmarinic-acid-pomegranate-curcumin.html


      Berberine inhibits HIF-1alpha expression via enhanced proteolysis

      https://pubmed.ncbi.nlm.nih.gov/15322253/


      How calcium affects oxygen formation

      https://www.nature.com/articles/nature13753/


      Copper and Metabolic Regulation

      https://link.springer.com/chapter/10.1007/978-1-4757-9432-8_7

      The Nutritional Relationships of Copper

      https://www.traceelements.com/Docs/The%20Nutritional%20Relationships%20of%20Copper.pdf


      Correlation of changes in HIF-1Ξ± and p53 expressions with vitamin B3 deficiency in skin cancer patients

      https://www.researchgate.net/publication/320616929


      Biotherapy with the Pineal Immunomodulating Hormone Melatonin versus Melatonin plus Aloe vera in Untreatable Advanced Solid Neoplasms

      https://www.karger.com/Article/Abstract/69427


      Long-term effectiveness of high-dose ornithine-aspartate on urea synthesis rate and portal hypertension in human liver cirrhosis

      https://www.sciencedirect.com/science/article/abs/pii/S0197018605000860


      The real face of HIF1Ξ± in the tumor process

      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507488/

      Remarks

      Having a high amount of calcium in your blood (Hypercalcemia) is a possible risk associated with advanced cancer. It is not caused by anything in your diet so you shouldn't need to alter what you eat.

      Primary hyperparathyroidism is the most common cause of high blood calcium levels. This happens when your parathyroid glands make excessive amounts of parathyroid hormone (PTH). Too much of this hormone will raise the level of calcium in your blood.

      (*)  If you have high histamine issues I wouldn't use Methylene blue right away or start at an even lower dose (1 drop of the solution as described below) or on the 2nd cycle of the protocol.

      16 1% MB drops in 30ml of water dissolving approx 1 gram of ascorbic acid will make a MB solution turn almost colorless and make LeucoMethylene Blue + DHA (Dehydroascorbic acid, the oxidized form of ascorbic acid). That's 8mg MB in a 30ml bottle, and each full dropper approx 0,5mg (500mcg) Methylene Blue, or about 12,5mcg per drop, or 50 mcg every 4 drops.

      Foods like cheese, chocolate, or wine are best avoided a few hours before or after (leuco)MB as these contain potent phytochemicals that can further inhibit aromatase (MB is a very potent aromatase inhibitor).

      (*) From Acerola, Camu Camu, or non-GMO ascorbic acid.

      (*) If this amount of magnesium is too hard on your stomach mix it with some milk. Avoid magnesium citrate. Good options are mg malate, mg glycinate, and mg chloride. If you use mg chloride crystals, dissolve in spring water not tap water. You could make some concentrated Mg chloride drops and then add a few drops to orange juice.


      Talk with your doctor before taking any new dietary supplement.

      If any of the substances or ingredients listed here makes you feel worse or bad, simply stop using them and maybe reintroduce them in the next cycle and see what happens. If something repeatedly makes you feel bad you shouldn't continue using it.

      BID = twice a day

      1 gram (g) is equal to 1000 milligrams (mg)

      1 milligram (mg) = 1000 micrograms (mcg)




      Saturday, October 17, 2020

      ATF4 and FAM129A protein expression is increased in PCa

      In this study, in vivo therapeutic silencing of the ATF4-FAM129A axis markedly inhibited tumor growth in a preclinical PCa model.

      Ursolic acid and Tomatidine, as potential agents and/or lead compounds for reducing ATF4 activity.

      References

      PΓ€llmann, N., LivgΓ₯rd, M., Tesikova, M. et al. Regulation of the unfolded protein response through ATF4 and FAM129A in prostate cancer. Oncogene 38, 6301–6318 (2019). https://doi.org/10.1038/s41388-019-0879-2


      Ebert SM, Dyle MC, Bullard SA, Dierdorff JM, Murry DJ, Fox DK, Bongers KS, Lira VA, Meyerholz DK, Talley JJ, Adams CM. Identification and Small Molecule Inhibition of an Activating Transcription Factor 4 (ATF4)-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy. J Biol Chem. 2015 Oct 16;290(42):25497-511. doi: 10.1074/jbc.M115.681445. Epub 2015 Sep 3. PMID: 26338703; PMCID: PMC4646196.


      Saturday, September 12, 2020

      Book Review: How to Starve Cancer, by Jane McLelland

      Published: 25th September 2018

      ISBN: 9780951951736

      Number Of Pages: 404

      A few days ago I got a copy of Jane McLelland's best-selling book ❝How to Starve Cancer❞. I bought the Kindle edition (US$9,90).

      Website: www.howtostarvecancer.com

      Cancer Progress and Treatments Timeline

      1994: Diagnosed with Cervical Cancer Stage 1b, at age 30. Treatments: Surgery, Radiation therapy,        and Chemotherapy.

      Gradually starts making changes to her diet (cutting out sugar, wheat and dairy, supplementing vitamins C and E, and glucosamine sulfate to manage the pain in her knee from a skiing accident.)

      1998: A cough appears.

      1999: Cancer has metastasized to the lungs ("a tumor the size of a golf ball"); Surgery. 

      She takes ginger, curcumin, and omega-3 to reduce inflammation, pre-surgery

      Other supplements she's taking at this point in time: 

        • Green tea
        • Ellagic acid
        • Resveratrol
        • Milk Thistle
        • Pycnogenol
        • B12 and folate
        • Glucosamine sulfate
        • CLA

      2000: Chemotherapy Gemcitabine, cisplatin, and 5FU. (until the summer of 2000, last 3 months on a      lower than regular dose.). After the first chemo round the SCC marker drops from almost 600 to            130, which is in the normal range (up to 150).

      Intravenous vitamin C. Started taking Berberine prior to Chemotherapy.

      2003: Live blood analysis, by Dr. Kenyon, reveals rouleaux formations. SCC markers in the normal range.

      Intravenous vitamin C.

      Starts taking dipyridamole, aspirin, and magnesium.

      Cocktail of repurposed drugs: metformin, statins, dipyridamole, aspirin, and etodolac.

      Stopped etodolac after 3 months, worried about her stomach lining.

      Stopped taking the statin after 5 months.

      2004: Bump in SCC markers (>200). Resumed her drug cocktail. More IV-C. Started taking Berberine again, which she had stopped taking in 2002.

      Two months later SCC markers drop again. CT scan was done, but no sign of disease.

      2007: Takes Cimetidine during a 3-month period, for its immune-stimulating effect. (she was worried    because of an outbreak of avian flu.)

      Jane talks about therapy-related leukemia, a cancer of the blood, yet in her book I can't find the official diagnosis of this cancer by her oncologist. Jane suspects this to be the case based on a blood test from Dr. Kenyon, showing rouleaux formations in the blood.

      This part is confusing, and important because she writes that her multidrug cocktail had stopped the progression of leukemia, "known to be impossible to cure....had I stumbled on a magic metabolic combination, a way to starve and conquer my cancer?". In a recent podcast with The Moss Report, she's asked if she had blood cancer and she doesn't give a clear answer to this question.

      The book contains a lot of information on drugs that are now being repurposed in the treatment of cancer. Note that at the time Jane started taking these medications very few people were using those drugs in cancer treatment. She credits her recovery from stage 4 cancer to her diet, exercise, off-label medication and supplements. Undeniably, standard treatment (surgery, RT, and/or chemo) played an important role in her recovery as well.

      It's an intriguing story of a long albeit relatively uneventful fight against cancer. Jane McLelland is a disciplined warrior, and she's come out victorious in her battle with cancer. 

      Starving Cancer


      I really like indoor plants, even so, there was a time when I always forgot to water them. One plant, however, would not die; The Snake Plant (Sansevieria). You can pull it out of a pot and not water it for months, it'll still look the same! Cancer can do what the snake plant does, and much more. In order to survive, cancer will even resort to cannibalism {Ref}.

      So, how does one starve cancer? In her book, Jane proposes a multifaceted approach to achieve this e.g. limiting glucose, reducing cancer's ability to make cholesterol, etc. Done properly, cancer is then left weak and vulnerable, easier to kill. This concept isn't new and has gained more support in recent years {Ref}. 

      Stem Cell Metro Map


      Jane McLelland created a map, it is an illustration of multiple nutrient pathways in cancer cells and the goal is to block those routes. This map represents the cancer stem cell and its function is to help guide the reader to the drugs, supplements, and therapies she proposes to starve cancer.

      The map is actually an isosceles triangle. The base of this triangle represents the fatty acid pathway, the left leg of the triangle is the glutamine pathway, and the right leg represents the Glucose pathway. In the center of the triangle is Acetyl-CoA, a molecule that participates in many biochemical reactions in protein, carbohydrate, and lipid metabolism.

      It's really the most important chapter of the book and needed more explanation in order to gain better insight on how to use the map. 

      Intravenous Vitamin C


      In an interview with Dr. Jeffrey Bland in 1982, Linus Pauling (1901 – 1994) talks about the benefit of vitamin C for heart disease and cancer but not once does he mention IVC. In that interview, Linus Pauling says he takes 12 grams of ascorbic acid crystals a day, a dosage he thinks is optimal but goes on to say that any amount below that dose even 500mg a day would be beneficial for general health. At a seminar in 1993, a year before his death at age 93, he was taking 18 grams of vitamin C daily {Ref}. Confirmation of the preference for oral administration can be found in the article "The orthomolecular treatment of cancer II. Clinical trial of high-dose ascorbic acid supplements in advanced human cancer" by Ewan Cameron (1922-1991) and Allan Campbell. Yet Jane McLelland claims Vitamin C should be administered intravenously "in the way Linus Pauling suggested". 




      Conclusion


      Cancer is very frightening but, in her book, Jane often dramatizes her situation and is much too harsh in her judgment of oncologists and the medical system. It's quite unfair. From reading her account there's no doubt in my mind that the medical care Jane received was beneficial to her recovery. For the reader with advanced cancer, this book might be very discouraging and doesn´t offer a clear path to follow up on.


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