Tuesday, November 10, 2020

Combination of Natural Supplements as Adjunct Cancer Therapy

Natural supplements can be very helpful adjuvant to drug therapies, for example through chemosensitization of tumor cells. Unfortunately, it seems that very often there's little or no follow-through when readily available natural products show great potential in cancer treatment. Here's a list of compounds with potential anticancer effects, and synergistic combinations.

  1. ArtemisininπŸ›ˆ 
      •  Magnolol   SulforaphaneπŸ›ˆ*          EGCg* IP6*
    •        HDACi πŸ›ˆ    → Melatonin   Curcumin     Berberine
    •  Butyrate* πŸ”΅(+ Zn)    Vit. D3πŸ›ˆ*(+ Mg)  Vitamin K2
    • → Allicin πŸ”΅
    •  AHCCπŸ›ˆ  FucoidanπŸ›ˆ (+ 500mg ascorbic acid)
  2.  CurcuminπŸ›ˆ
    •  DHA docosahexaenoic acid  *ButyrateπŸ›ˆ  CitrateπŸ›ˆ 
              •  Melatonin 
    •  *EGCgπŸ›ˆ πŸ‹
      • →  Luteolin 
      •  *IP6 & InositolπŸ›ˆ (+ 10mg Zn) (+ 500mg ascorbic acid)
      • ↓ Milk Thistle  
    •                  Black cumin seed oilπŸ›ˆ  ResolvinsπŸ›ˆ 
    •       * Vitamin D3   Resolvins πŸ”΅ (+ Mg)
    •               *Sulforaphane→↖ LycopeneπŸ›ˆ
    •                           (+ Se)  
    • *Sulforaphane πŸ”΅  (aspirin) πŸŸͺ
    •  Ascorbic acidπŸ›ˆ (don't combine with Artemisinin)
      • → Vitamin K2
      • Riboflavin
      •  Ashwagandha (T⏶ *Sulforaphane
    •            ↘ ↓ Holy basil/Tulsi
    •  Galangal
      •  *BerberineπŸ›ˆ
      •   Ginger  Licorice 
    •  Azadirachta indica/Neem
    • Mistletoe  ChagaπŸ›ˆ 
      πŸ’Š To improve absorption and bioavailability of fat-soluble supplements take with some fat e.g. ghee butter or coconut oil. Curcumin supplements are best taken with DHA. In addition, special formulations can offer improved bioavailability. The optimal dosing of the compounds mentioned in this blog is not known. Please check the information πŸ›ˆ on each compound for suggested dosing and more.

      Supplements should only be taken under the supervision of a healthcare provider. Supplements or herbal preparations shouldn't be used in combination with chemotherapy, radiotherapy, immunotherapy, or any other cancer treatment unless the safety and efficacy of such combinations are established. It's especially important to make sure anything you add to the standard treatment will further improve the efficacy of that treatment, hence the importance of discussing any addition of supplements or dietary interventions during active cancer treatment with the oncologist.

      ⚡ Potential Synergistic Effects

      Often a natural compound exhibits anticancer activity at concentrations that are too high to get any significant benefit (in vitro concentrations not achievable in vivo). That's why synergies may be vital because when taken in the right combination, some compounds become effective at much lower concentrations. Synergistic combinations can also be used to overcome chemoresistance in cancer cells. Such coactive combinations applied in specific sequences may be very powerful anti-cancer strategies.

       synergy with Artemisinin
       artemisinin with HDACi
       possible additive or synergistic antineoplastic effect
      possibly synergistic
      likely to be a good combination ⇒ likely to be a good combination but in a specific order, after a then b
        the combination may offer hepaprotective effects
       Metformin: possible additive effects/potentiation with Vitamin D, Sodium Butyrate, and Berberine (metformin is a prescription drug to treat high blood sugar levels caused by type 2 diabetes).   Caution with mutations in BRAF.
      πŸ’Š Because of the low bioavailability of Curcumin, consider combining curcumin with other natural products that may enhance curcumin's anticancer properties: Epigallocatechin gallate, BerberineUrsolic acid, Ginger, Galangal, Allicin, Ascorbic acid, DHA, VItamin D3.

      (+ ): depending on your diet you may need to supplement this mineral. Many if not most cancer patients have mineral deficiencies and temporary supplementation should be beneficial.{ref}

      * * * = check matching colors for more potentially additive or synergistic combinations.


      πŸƒ  Aerobic activity improves outcomesAt least 20 studies of people with breast, colorectal, prostate, and ovarian cancer have suggested that physically active cancer survivors have a lower risk of cancer recurrence and improved survival compared with those who are inactive.

      🌞  Sunshine, Vitamin D, and cancer

      πŸ” 10 Dietary Strategies to put the brakes on cancer growth






       Ზ    A good article on the mind/body connection in healing.



      🦷 Dental health and disease


      Cautions regarding combining supplements and medication


      ✅ Read this first: Warnings, Terms of Use & Disclaimer

      WARNING Don't exceed the maximum suggested dosagesstart with the lowest possible dose and gradually increase if no side effect is observed.

      If you take medications always check if the supplement(s) can be combined with those drugs, especially with chemotherapy, diabetes medications, anticoagulant and antiplatelet medications (including aspirin), benzodiazepines, etc. Ask a 'Drug Interaction Specialist' Online.

      Stop taking supplements a week before surgery, or consult with your surgeon.

      To combine various supplements add one at a time, start with the lowest possible dose, and gradually increase if no side effect is observed.

      To discontinue a supplement taper off by cutting to a half dose for a week before stopping.

      Dosage, but also time is crucial to achieving a therapeutic effect.


      A partial list of studies and reviews:

      1. A randomized study of chemotherapy versus biochemotherapy with chemotherapy plus Aloe arborescens in patients with metastatic cancer
      2. From ancient herb to modern drug: Artemisia annua and artemisinin for cancer therapy.
      3. Methods for the treatment of cancer using piperlongumine and piperlongumine analogs
      4. The central role of citrate in the metabolism of cancer cells. "citrate has demonstrated anti-cancer properties when administered in excess, sensitizing cancer cells to chemotherapy."
      5. Turkey Tail and Polysaccharide-K
      6. Red (Panax) ginseng and cancer treatment.
      7. Absorption, metabolism, anti-cancer effect and molecular targets of epigallocatechin gallate (EGCG): An updated review.
      8. Activation of tumor suppressor LKB1 by honokiol abrogates cancer stem-like phenotype in breast cancer via inhibition of oncogenic Stat3.
      9. Curcumin decreases Warburg effect in cancer cells by down-regulating pyruvate kinase M2 via mTOR-HIF1Ξ± inhibition
      10. Berberine Enhances Chemosensitivity and Induces Apoptosis Through Dose-orchestrated AMPK Signaling in Breast Cancer
      11. Curcumin And Berberine – Offers New Hope In The Treatment Of Breast And Other Cancers?
      12. Anti-cancer effects of Gynostemma pentaphyllum (Thunb.) Makino (Jiaogulan)
      13. Withaferin A (WFA) inhibits tumor growth and metastasis by targeting ovarian cancer stem cells
      14. Therapeutic Interventions Using Ursolic Acid for Cancer Treatment
      15. Melatonin for the prevention and treatment of cancer
      16. Recent advances in the anti-cancer properties of Nigella sativa, a widely used food additive
      17. Phycocyanin: A Potential Drug for Cancer Treatment
      18. Pyrroloquinoline quinone induces chondrosarcoma cell apoptosis by increasing intracellular reactive oxygen species
      19. Oleanolic Acid Alters Multiple Cell Signaling Pathways: Implication in Cancer Prevention and Therapy
      20. Molecular Iodine Induces Caspase-independent Apoptosis in Human Breast Carcinoma Cells Involving the Mitochondria-mediated Pathway
      21. Brown Seaweed Fucoidan Inhibits Cancer Progression by Dual Regulation of mir-29c/ADAM12 and miR-17-5p/PTEN Axes in Human Breast Cancer Cells
      22. D-limonene rich volatile oil from blood oranges inhibits angiogenesis, metastasis and cell death in human colon cancer cells
      23. A novel therapeutic anticancer property of raw garlic extract via injection but not ingestion
      24. Nature curing cancer – review on structural modification studies with natural active compounds having anti-tumor efficiency
      25. Clinical Response of Metastatic Breast Cancer to Multi-targeted Therapeutic Approach: A Single Case Report
      26. Effects of supplements on medicines
      27. How does turmeric/curcumin interact with coffee/caffeine?
      28. Microalgae in modern cancer therapy: Current knowledge
      29. Role of Magnesium in Vitamin D Activation and Function
      30. Vegetables, fruit, and colon cancer in the Iowa Women's Health Study
      31. Tumor Angiogenesis as a Target for Dietary Cancer Prevention
      32. Short chain fatty acids enriched fermentation metabolites of soluble dietary fibre from Musa paradisiaca drives HT29 colon cancer cells to apoptosis
      33. Natural Products and Synthetic Analogs as a Source of Antitumor Drugs
      34. Ursolic Acid—A Pentacyclic Triterpenoid with aWide Spectrum of Pharmacological Activities
      35. Plants Against Cancer: A Review on Natural Phytochemicals in Preventing and Treating Cancers and Their Druggability
      36. Salvia miltiorrhiza: Chemical and pharmacological review of a medicinal plant
      37. Phytochemicals of garlic: Promising candidates for cancer therapy
      38. Selenium a Potential Treatment for Cancer Metastasis
      39. Phenylbutyrate-induced glutamine depletion in humans: effect on leucine metabolism.
      40. Getting the Balance Right – Vitamin D Co-Factors
      41. Cancer Cells Upregulate NRF2 Signaling to Adapt to Autophagy Inhibition
      42. Autophagy supplies the amino acids necessary for driving mitochondrial OXPHOS in glycolysis-suppressed cells
      43. Synergistic Interactions in Natural Products and Medication
      44. Curcumin Nicotinate Selectively Induces Cancer Cell Apoptosis and Cycle Arrest through a P53-Mediated Mechanism
      45. Retrolective Studies on the Survival of Cancer Patients Treated With Mistletoe Extracts: A Meta-analysis
      46. Upon glycolytic suppression in multiple types of tumor cells, intracellular energy metabolism is reprogrammed toward mitochondrial OXPHOS in an autophagy-dependent manner to ensure cellular survival.
      47. Role of Plants in Stage IV Cancer
      48. Using the Heat-Shock Response To Discover Anticancer Compounds that Target Protein Homeostasis "Surprisingly, many of the strongly active compounds identified were natural products representing five diverse chemical classes (limonoids, curvularins, withanolides, celastraloids, and colletofragarones)"
      49. Neem components as potential agents for cancer prevention and treatment
      50. Anticancer and Cytotoxic Potential of Turmeric (Curcuma longa), Neem (Azadirachta indica), Tulasi (Ocimum sanctum) and Ginger (Zingiber officinale) Extracts on HeLa cell line
      51. Curcumin-Artesunate Based Polymeric Nanoparticle; Antiplasmodial and Toxicological Evaluation in Murine Model
      52. https://www.degruyter.com/view/journals/bmc/4/3/article-p287.xml?language=en
      53. Dying Cells Have Cellular 'Death Code'
      54. Peptides & Proteins
      55. Host defense peptides and peptidomimetics as new weapons for cancer treatment
      56. Synthetic and natural iron chelators: therapeutic potential and clinical use
      57. Natural Compound Histone Deacetylase Inhibitors (HDACi): Synergy with Inflammatory Signaling Pathway Modulators and Clinical Applications in Cancer
      58. Research Strategies in the Study of the Pro-Oxidant Nature of Polyphenol Nutraceuticals
      59. Inhibitors of DNA Methyltransferases From Natural Sources: A Computational Perspective
      60. Pathways in cancer - Homo sapiens (human)
      61. The TNF Paradox in Cancer Progression and Immunotherapy
      62. Potential risks associated with traditional herbal medicine use in cancer care
      63. Lysine-carnitine conversion in normal and undernourished adult men-suggestion of a nonpeptidyl pathway
      64. Why the tumor cell metabolism is not that abnormal
      65. Understanding the synergy of cancer growth to advance care
      66. Niacin ameliorates oxidative stress, inflammation, proteinuria, and hypertension in rats with chronic renal failure
      67. The reverse Warburg effect is likely to be an Achilles' heel of cancer that can be exploited for cancer therapy
      68. The Effect of Zinc and Lysine Supplementation on Infection Rate and CD4 Count

      Saturday, October 17, 2020

      ATF4 and FAM129A protein expression is increased in PCa

      In this study, in vivo therapeutic silencing of the ATF4-FAM129A axis markedly inhibited tumor growth in a preclinical PCa model.

      Ursolic acid and Tomatidine, as potential agents and/or lead compounds for reducing ATF4 activity.

      References

      PΓ€llmann, N., LivgΓ₯rd, M., Tesikova, M. et al. Regulation of the unfolded protein response through ATF4 and FAM129A in prostate cancer. Oncogene 38, 6301–6318 (2019). https://doi.org/10.1038/s41388-019-0879-2


      Ebert SM, Dyle MC, Bullard SA, Dierdorff JM, Murry DJ, Fox DK, Bongers KS, Lira VA, Meyerholz DK, Talley JJ, Adams CM. Identification and Small Molecule Inhibition of an Activating Transcription Factor 4 (ATF4)-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy. J Biol Chem. 2015 Oct 16;290(42):25497-511. doi: 10.1074/jbc.M115.681445. Epub 2015 Sep 3. PMID: 26338703; PMCID: PMC4646196.


      Saturday, September 12, 2020

      Book Review: How to Starve Cancer, by Jane McLelland

      Published: 25th September 2018

      ISBN: 9780951951736

      Number Of Pages: 404

      A few days ago I finally got a copy of Jane McLelland's best-selling book ❝How to Starve Cancer❞. I bought the Kindle edition (US$9,90).

      Website: www.howtostarvecancer.com

      Cancer Progress and Treatments Timeline

      1994: Diagnosed with Cervical Cancer Stage 1b, at age 30. Treatments: Surgery, Radiation therapy,        and Chemotherapy.

      Gradually starts making changes to her diet (cutting out sugar, wheat and dairy, supplementing vitamins C and E, and glucosamine sulfate to manage the pain in her knee from a skiing accident.)

      1998: A cough appears.

      1999: Cancer has metastasized to the lungs (a tumor the size of a golf ball); Surgery. 

      She takes ginger, curcumin, omega-3 to reduce inflammation, pre-surgery

      Other supplements she's taking at this point in time: 

        • Green tea
        • Ellagic acid
        • Resveratrol
        • Milk Thistle
        • Pycnogenol
        • B12 and folate
        • Glucosamine sulfate
        • CLA

      2000: Chemotherapy Gemcitabine, cisplatin, and 5FU. (until the summer of 2000, last 3 months on a      lower than regular dose.). After the first chemo round the SCC marker drops from almost 600 to            130, which is in the normal range (up to 150).

      Intravenous vitamin C. Started taking Berberine prior to Chemotherapy.

      2003: Live blood analysis, by Dr. Kenyon, reveals rouleaux formations. SCC markers in the normal range.

      Intravenous vitamin C.

      Starts taking dipyridamole, aspirin, and magnesium.

      Cocktail of repurposed drugs: metformin, statins, dipyridamole, aspirin, and etodolac.

      Stopped etodolac after 3 months, worried about her stomach lining.

      Stopped taking the statin after 5 months.

      2004: Bump in SCC markers (>200). Resumed her drug cocktail. More IV-C. Started taking Berberine again, which she had stopped taking in 2002.

      Two months later SCC markers drop again. CT scan was done, but no sign of disease.

      2007: Takes Cimetidine during a 3 month period, for its immune-stimulating effect. (she was worried    because of an outbreak of avian flu.)

      Jane talks about therapy-related leukemia, a cancer of the blood, yet in her book I can't find the official diagnosis of this cancer by her oncologist. Jane suspects this to be the case based on a blood test from Dr. Kenyon, showing rouleaux formations in the blood.

      This part is confusing, and important because she writes that her multidrug cocktail had stopped the progression of leukemia, "known to be impossible to cure....had I stumbled on a magic metabolic combination, a way to starve and conquer my cancer?". In a recent podcast with The Moss Report, she's asked if she had blood cancer and she doesn't give a clear answer to this question.

      The book contains a lot of information on drugs that are now being repurposed in the treatment of cancer. Note that at the time Jane started taking these medications very few people were using those drugs in cancer treatment. She credits her recovery from stage 4 cancer to her diet, exercise, off-label medication and supplements. Undeniably, standard treatment (surgery, RT, and/or chemo) played an important role in her recovery as well.

      It's an intriguing story of a long albeit relatively uneventful fight against cancer. Jane McLelland is a disciplined warrior, and she's come out victorious in her battle with cancer. 

      Starving Cancer


      I really like indoor plants, even so, there was a time when I always forgot to water them. One plant, however, would not die; The Snake Plant (Sansevieria). You can pull it out of a pot and not water it for months, it'll still look the same! If my objective was to kill the Sansevieria, depriving it of nutrients would leave me quite frustrated.

      Cancer can do what the snake plant does, and much more. In order to survive, cancer will even resort to cannibalism {Ref}.

      So, how does one starve cancer? In her book, Jane proposes a multifaceted approach to achieve this e.g. limiting glucose, reducing cancer's ability to make cholesterol, etc. Done properly, cancer is then left weak and vulnerable, easier to kill. This concept isn't new but has gained more support in recent years {Ref}. Robert A. Nagourney, MD (board-certified in internal medicine, medical oncology, and hematology) is also a proponent of turning off the energy in cancer cells, which he calls Metabolomics. {video}.

      Stem Cell Metro Map


      Jane McLelland created this map, it is an illustration of multiple nutrient pathways in cancer cells and the goal is to block those routes. This map represents the cancer stem cell and its function is to help guide the reader to the drugs, supplements, and therapies she proposes to starve cancer.

      The map is actually an isosceles triangle. The base of this triangle represents the fatty acid pathway, the left leg of the triangle is the glutamine pathway, and the right leg represents the Glucose pathway. In the center of the triangle is Acetyl-CoA, a molecule that participates in many biochemical reactions in protein, carbohydrate, and lipid metabolism.

      It's really the most important chapter of the book and needed more explanation in order to gain better insight on how to use the map. 

      Conclusion


      ⭐⭐★★★

      I had to put this book down several times. Cancer is very frightening but, in her book, Jane often dramatizes her situation and is much too harsh in her judgment of oncologists and the medical system. It's quite unfair. Jane probably wouldn't be alive without the medical care she received. To the reader with advanced cancer, this book might be very discouraging and doesn´t offer a clear path to follow up on.


      Sunday, August 25, 2019

      Ovarian Cancer Treatment

      Ovarian Cancer FDA Approved Treatments to Date


      • Cisplatin (1978) 
      • Altretamine (1990)
      • Carboplatin (1991)
        • → see cisplatin
        • → Vitamin D3 {study}
      • Paclitaxel (Taxol)(1992)
      • Topotecan (1996)
      • Pegylated Liposomal Doxorubicin, PLD (2000)
      • Gemcitabine + Carboplatin (2006) → reduced-dose-doublet schedule
      • Bevacizumab (Avastin) + chemo platinum resistant (2014)
      • Bevacizumab + chemo platinum sensitive (2016)
      • Rucaparib (2016) PARP inhibitor
      • Niraparib (2017) PARP inhibitor {clinical trial results}
      • Olaparib (2018) PARP inhibitor
        • → Alantolactone (selective STAT3 inhibitor) {study}




      ⌘ Natural PARP inhibitors

      • Puerarin Sources: Kudzu Root Extract
      • Chlorogenic acid  Sources: Green coffee bean extractπŸ›ˆ
      • Biochanin Sources: Red clover
      • Phloretin Sources: Manchurian apricot (Prunus mandshurica)
      • Hesperetin http://nutrition.merschat.com/foods-by-nutrient.cgi?Nutr_No=759
      • Quercetin capers, red onions, unsweetened dark chocolate(85% cocoa), more
        • Quercetin: a natural compound for ovarian cancer treatment {study}
      • Niacinamide Available as a supplement study
      • Naringin Grapefruit*, citrus fruit, bergamot, sour orange, tart cherries, tomatoes, cocoa, oregano, oil of oregano, water mint, Drynaria, and beans.

      *Eating grapefruit or drinking grapefruit juice while taking certain medications can lead to higher levels in your blood and more side effects. With some drugs, even small amounts of grapefruit can cause severe side effects. Therefore, the combination should be avoided.

      ⌘ HDAC Inhibition


      • "Ovarian clear cell carcinoma (OCCC) is associated with a frequent loss in ARID1A function. ARID1A reportedly suppresses histone deacetylase (HDAC)6 in OCCC directly" {article}
      • Natural product-derived therapy for gynecologic cancers (HDAC6) "pharmacological formulations encompassing “Berberine (BER), Dihydroartemisinin (DHA), and Curcumin (CUR) or their analogues, either alone or in combination with other known anticancer drugs” may be used to inhibit the progression of ARID1A-mutated ovarian cancers "
      • Class I-Histone Deacetylase (HDAC) Inhibition is Superior to pan-HDAC Inhibition in Modulating Cisplatin Potency in High-Grade Serous Ovarian Cancer Cell Line {Ref}
      • Scriptaid (HDACi) + bortezomib (proteasome inhibitor): {study} ⚠ Green tea polyphenols block the anticancer effects of bortezomib
      • Identification of a cancer stem cell-specific function for the histone deacetylases, HDAC1 and HDAC7, in breast and ovarian cancer {study}


      ⌘ Angiogenesis 

      Ovarian cancer → vascular endothelial growth factor (VEGF) driven tumor

      ⌘ mTOR inhibition 

      • Vistusertib

      ⌘ FAK inhibition 



      ⌘ ALDH1A inhibitor


      https://www.tocris.com/products/673-a_6934

       MIP-1Ξ² inhibition

      "macrophages produce a protein called MIP-1Ξ², which causes the mesothelial cells to produce more of an adhesion protein called P-selectin. P-selectin, in turn, allows the cancer cells to stick." {article}


       ⌘ HER2 overexpression

      • Magnolol down-regulates HER2 gene expression, leading to inhibition of HER2-mediated metastatic potential in ovarian cancer cells. {study}
        •  honokiol, magnolol also downregulate P-gp expression {study}
      • Danshen
      • Echinacea
      • Curcumin

      MMP-9 overexpression


       CD36 downregulation

      • Cruciferous "Subgroup analyses showed only yellow and cruciferous vegetables to significantly favor survival" {ref|ref}


      Supplements



        Relevant studies, articles, and reviews

        Last updated: February 12, 2021

         *  potential synergy 

        Thursday, September 20, 2018

        List of Cancer-Fighting Natural Compounds

        The following foods, herbs, oils, and natural supplements have anti-cancer properties
        1. AHCC πŸ›ˆ
        2. Allicin πŸ›ˆ
        3. Aloe Vera πŸ›ˆ
        4. Apigenin πŸ›ˆ
        5. Andrographis extract πŸ›ˆ
        6. Artemisinin πŸ›ˆ
        7. Ascorbic acid πŸ›ˆ
        8. Ashitaba πŸ›ˆ
        9. Astragalus πŸ›ˆ 
        10. Ashwagandha πŸ›ˆ
        11. Baicalin πŸ›ˆ
        12. Berberine πŸ›ˆ
        13. Beta-Glucan πŸ›ˆ
        14. Betulin πŸ›ˆ
        15. Bee Propolis πŸ›ˆ 
        16. Bitter Melon πŸ›ˆ 
        17. Black cumin seed oil πŸ›ˆ
        18. Boswellia πŸ›ˆ
        19. Bovine Tracheal Cartilage πŸ›ˆ 
        20. Butyrate πŸ›ˆ 
        21. Calcium D-glucarate πŸ›ˆ 
        22. Cannabis oils πŸ›ˆ
        23. Chaga πŸ›ˆ
        24. Chlorogenic acid πŸ›ˆ 
        25. Citric Acid πŸ›ˆ 
        26. Citrus Pectin πŸ›ˆ
        27. Coenzyme Q10 πŸ›ˆ
        28. C-phycocyanin πŸ›ˆ
        29. Cranberry πŸ›ˆ
        30. Curcumin πŸ›ˆ
        31. Danshen πŸ›ˆ 
        32. D-Limonene πŸ›ˆ
        33. Epigallocatechin-3-gallate πŸ›ˆ 
        34. Ellagitannins πŸ›ˆ 
        35. Enzymes πŸ›ˆ
        36. Fucoidan πŸ›ˆ
        37. Galangal πŸ›ˆ
        38. Garcinol πŸ›ˆ 
        39. Ginger πŸ›ˆ
        40. Graviola πŸ›ˆ
        41. Grape Seed Extract πŸ›ˆ
        42. Hericium Erinaceus extract πŸ›ˆ
        43. Honokiol πŸ›ˆ
        44. Hydroxycitric acid πŸ›ˆ
        45. IP6 πŸ›ˆ 
        46. Iodine πŸ›ˆ
        47. Jiaogulan πŸ›ˆ 
        48. Laetrile πŸ›ˆ
        49. Larch arabinogalactan πŸ›ˆ
        50. Luteolin πŸ›ˆ
        51. Lycopene πŸ›ˆ 
        52. Melatonin πŸ›ˆ
        53. Mistletoe πŸ›ˆ
        54. Moringa πŸ›ˆ 
        55. MSM πŸ›ˆ
        56. Myricetin πŸ›ˆ
        57. Nattokinase πŸ›ˆ 
        58. Oil of Oregano πŸ›ˆ 
        59. Oleanolic acid  πŸ›ˆ
        60. Olive Leave Extract πŸ›ˆ
        61. Panax Ginseng πŸ›ˆ
        62. Pau D'Arco πŸ›ˆ
        63. Piperlongumine πŸ›ˆ
        64. PQQ πŸ›ˆ
        65. Pterostilbene πŸ›ˆ 
        66. Quercetin πŸ›ˆ
        67. Reishi πŸ›ˆ 
        68. R-(Alpha) Lipoic Acid πŸ›ˆ 
        69. Resolvins πŸ›ˆ
        70. Resveratrol πŸ›ˆ
        71. Sea cucumber πŸ›ˆ
        72. Silibinin πŸ›ˆ 
        73. Sodium Bicarbonate πŸ›ˆ
        74. Sulforaphane πŸ›ˆ
        75. Tinospora cordifolia πŸ›ˆ 
        76. Triphala πŸ›ˆ
        77. Tripterygium wilfordii πŸ›ˆ
        78. Ursolic Acid πŸ›ˆ 
        79. Vitamin D πŸ›ˆ
        80. Zhi Zi Gardenia fruit πŸ›ˆ
        🟠 See the home page for more information on the possible synergistic combinations for orange-colored compounds in the above list.

        Special Formula Supplements

        • Avemar πŸ›ˆ
        • Biobran MGN-3 πŸ›ˆ
        • Synergy Combination EpiQuercican™ Intensive πŸ›ˆ
        • Ukrain πŸ›ˆ
        • Peptides L-Canaline, ... πŸ›ˆ
          Never before did we have access to such a wide variety of supplements and natural products that can help beat cancer. Many of these natural products are inexpensive and most have little or no known toxicity at the recommended dosages. 

          There's no single natural cancer cure but there are many natural remedies that, combined with standard medical care, can help you manage and improve your odds of reversing cancer.



          The anticancer potential of the nutritional supplements listed here has been established either by laboratory and/ or animal studies, very few controlled human studies are done on nutritional supplements.



          Combination of Natural Supplements as Adjunct Cancer Therapy

          Natural supplements can be very helpful adjuvant to drug therapies, for example through chemosensitization of tumor cells. Unfortunately, i...