Natural supplements can be very helpful adjuvant to drug therapies, for example through chemosensitization of tumor cells. Unfortunately, it seems that very often there's little or no follow-through when readily available natural products show great potential in cancer treatment. Here's a list of compounds with potential anticancer effects, and synergistic combinations. The below-mentioned are some of the safest, most accessible, effective, and broad-spectrum anticancer natural substances.
- Artemisininπ CT FER AA
- → HDACi π → Melatonin → Curcumin ┘→ Berberine* → Graviola
- + PDL1i π Ellagic acid HIF↑ → ↑ Quercetin (ld) ↑
- → Butyrate*π π΅(+ Se, Zn) →↑Vit. D3π*+ Mg → Vitamin K2
- → Aloe Vera MT
- → Allicin π΅ CCAA
- → AHCCπ → Fucoidanπ (+ 200mg vitamin C)
- ↳ Curcuminπ MT, RMDR → Emodin → (celecoxib) πͺCOX-2 → Luteolin (ld)
- → DHA docosahexaenoic acid →*Butyrateπ ⇒ Citric acidπ GI, LR↓→ Graviola
- → Melatonin →↑Andrographis↑π→Berb.*
- → Shikonin ICD ⌟
- → *EGCgπ π → ↓ Quercetin (ld) πͺ ↗ → ↓Grapeseed extract AA → Phellinus linteus
- → Luteolin (ld) ↓ → Sulforaphane AI
- → *IP6 & Inositolπ (+ 10mg Zn) (+ 200mg vitamin C)
- → Lipoic acidπ ↑MT, RMDR→ Hydroxycitrate
- →↓ Milk Thistle → Baicalein HIF AA
- ↓ Black cumin seed oilπ → Emodin
- → ↓ Vitamin D3 π ☼ * → ↓ (aspirin) πͺ
- *Sulforaphane→↖ Lycopeneπ π AI FAK → Triphala
- ↘ (+ Se) → Vitamin E as alpha-tocopheryl succinate
- →*Sulforaphane π₯¦ → Dihydrocaffeic Acid π
- → Vitamin C π (don't combine high dose vitamin c with Artemisinin)
- → Vitamin K2→ Phosphatidylcholine
- → Magnesium LR
- → Juglone CCAA
- → Riboflavin E⏷
- → Ashwagandha (T⏶) → *Sulforaphane π΅
- → Galangal → Holy basil/Tulsi ↗
- → Azadirachta indica/Neem
- → Piperlongumine FER→ Sanguinarine → Berberine* → Caffeine
- → Carnosic acid ↓ πΏ
- Mistletoe AA π΅→ Chagaπ → Rosmarinic acid EGFR CAI
π To improve absorption and bioavailability of fat-soluble supplements take with some fat e.g. ghee butter or coconut oil. Curcumin supplements are best taken with DHA. In addition, special formulations can offer improved bioavailability. The optimal dosing of the compounds mentioned in this blog is not known. Please check the information π on each compound for suggested dosing and more.
π It may be a good idea to take anticancer supplements right before sleep at night and to include a time during the night in your supplementation schedule e.g. 3AM "study suggests that nighttime is the right time for cancer to grow and spread in the body and that administering certain treatments in time with the body's day-night cycle could boost their efficiency"{ref}.
⚡ Potential Synergistic Effects
A natural compound may exhibit anticancer activity but at concentrations that are too high to get any significant benefit (in vitro concentrations not achievable in vivo). However, if synergies exist those same substances may become noticeably effective at lower concentrations. Such combinations can also be used to overcome drug resistance or to sensitize cancer cells to therapeutic agents. A multi-layered approach using coactive combinations of natural substances applied in specific sequences may be a very powerful anti-cancer strategy.
→ anticancer synergy with Artemisinin
→ anticancer synergy with HDACi
→ possible additive or synergistic antineoplastic effect
→ possibly synergistic
→ likely to be a good antineoplastic combination ⇒ sequential
→ possibly synergistic
→ likely to be a good antineoplastic combination ⇒ sequential
→ the combination may offer hepatoprotective effects
→ attenuates DOX-induced kidney injury
(ld) low dose
(+ ): depending on your diet you may need to supplement this mineral. Many if not most cancer patients have mineral deficiencies and temporary supplementation should be beneficial.{ref}. Best Se is organic selenium.
(....) OTC drugs
* * * * * * = check matching colors for more potentially additive or synergistic combinations.
πΆ be aware of drug interactions.
Anticancer Mechanism
- ICD Immunogenic cell death
- GI inhibitor of glycolysis
- CT cytotoxic
- RMDR reversing multidrug resistance
- MT multiple targets
- CCAA cell cycle arrest and apoptosis
- FAS fatty acid synthase inhibition
- AA anti-angiogenic
- EGFR epidermal growth factor receptor Inhibition
- LR lactate reduction potential
- FER ferroptosis
- AMPK ampk activator
- COX-2 cox-2 inhibitor
- AI anti-inflammatory
- FAK focal adhesion kinase downregulation
- SERM selective estrogen receptor modulator
- CAI carbonic anhydrase inhibitor
- HIF hypoxia-inducible factor inhibition
π 10 Dietary Strategies to put the brakes on cancer growth
π° Cancer and Insulin
π What causes cancer?
π FAQ
Cautions regarding the combination of supplements and medication
✅ Read this first: Warnings, Terms of Use & Disclaimer
CAUTION Don't exceed the maximum suggested dosages, start with the lowest possible dose and gradually increase if no side effect is observed.
If you take medications always check if the supplement(s) can be combined with those drugs, especially with chemotherapy, diabetes medications, anticoagulant and antiplatelet medications (including aspirin), benzodiazepines, etc. Ask a 'Drug Interaction Specialist' Online.
Stop taking supplements a week before surgery, or consult with your surgeon.
To combine various supplements add one at a time, start with the lowest possible dose, and gradually increase if no side effect is observed.
To discontinue a supplement taper off by cutting to a half dose for a week before stopping.
Dosage, but also time is crucial to achieving a therapeutic effect.
Dosage, but also time is crucial to achieving a therapeutic effect.
Supplements should only be taken under the supervision of a healthcare provider. Supplements or herbal preparations shouldn't be used in combination with chemotherapy, radiotherapy, immunotherapy, or any other cancer treatment unless the safety and efficacy of such combinations are established. It's especially important to make sure anything you add to the standard treatment will further improve the efficacy of that treatment, hence the importance of discussing any addition of supplements or dietary interventions during active cancer treatment with the oncologist.
Last updated: Sunday, May 15, 2022.
A partial list of studies and reviews:
- A randomized study of chemotherapy versus biochemotherapy with chemotherapy plus Aloe arborescens in patients with metastatic cancer
- From ancient herb to modern drug: Artemisia annua and artemisinin for cancer therapy.
- Methods for the treatment of cancer using piperlongumine and piperlongumine analogs
- The central role of citrate in the metabolism of cancer cells. "citrate has demonstrated anti-cancer properties when administered in excess, sensitizing cancer cells to chemotherapy."
- Turkey Tail and Polysaccharide-K
- Red (Panax) ginseng and cancer treatment.
- Absorption, metabolism, anti-cancer effect and molecular targets of epigallocatechin gallate (EGCG): An updated review.
- Activation of tumor suppressor LKB1 by honokiol abrogates cancer stem-like phenotype in breast cancer via inhibition of oncogenic Stat3.
- Curcumin decreases Warburg effect in cancer cells by down-regulating pyruvate kinase M2 via mTOR-HIF1Ξ± inhibition
- Berberine Enhances Chemosensitivity and Induces Apoptosis Through Dose-orchestrated AMPK Signaling in Breast Cancer
- Curcumin And Berberine – Offers New Hope In The Treatment Of Breast And Other Cancers?
- Anti-cancer effects of Gynostemma pentaphyllum (Thunb.) Makino (Jiaogulan)
- Withaferin A (WFA) inhibits tumor growth and metastasis by targeting ovarian cancer stem cells
- Therapeutic Interventions Using Ursolic Acid for Cancer Treatment
- Melatonin for the prevention and treatment of cancer
- Recent advances in the anti-cancer properties of Nigella sativa, a widely used food additive
- Phycocyanin: A Potential Drug for Cancer Treatment
- Pyrroloquinoline quinone induces chondrosarcoma cell apoptosis by increasing intracellular reactive oxygen species
- Oleanolic Acid Alters Multiple Cell Signaling Pathways: Implication in Cancer Prevention and Therapy
- Molecular Iodine Induces Caspase-independent Apoptosis in Human Breast Carcinoma Cells Involving the Mitochondria-mediated Pathway
- Brown Seaweed Fucoidan Inhibits Cancer Progression by Dual Regulation of mir-29c/ADAM12 and miR-17-5p/PTEN Axes in Human Breast Cancer Cells
- D-limonene rich volatile oil from blood oranges inhibits angiogenesis, metastasis and cell death in human colon cancer cells
- A novel therapeutic anticancer property of raw garlic extract via injection but not ingestion
- Nature curing cancer – review on structural modification studies with natural active compounds having anti-tumor efficiency
- Clinical Response of Metastatic Breast Cancer to Multi-targeted Therapeutic Approach: A Single Case Report
- Effects of supplements on medicines
- How does turmeric/curcumin interact with coffee/caffeine?
- Microalgae in modern cancer therapy: Current knowledge
- Role of Magnesium in Vitamin D Activation and Function
- Vegetables, fruit, and colon cancer in the Iowa Women's Health Study
- Tumor Angiogenesis as a Target for Dietary Cancer Prevention
- Short chain fatty acids enriched fermentation metabolites of soluble dietary fibre from Musa paradisiaca drives HT29 colon cancer cells to apoptosis
- Natural Products and Synthetic Analogs as a Source of Antitumor Drugs
- Ursolic Acid—A Pentacyclic Triterpenoid with aWide Spectrum of Pharmacological Activities
- Plants Against Cancer: A Review on Natural Phytochemicals in Preventing and Treating Cancers and Their Druggability
- Salvia miltiorrhiza: Chemical and pharmacological review of a medicinal plant
- Phytochemicals of garlic: Promising candidates for cancer therapy
- Selenium a Potential Treatment for Cancer Metastasis
- Phenylbutyrate-induced glutamine depletion in humans: effect on leucine metabolism.
- Getting the Balance Right – Vitamin D Co-Factors
- Cancer Cells Upregulate NRF2 Signaling to Adapt to Autophagy Inhibition
- Autophagy supplies the amino acids necessary for driving mitochondrial OXPHOS in glycolysis-suppressed cells
- Synergistic Interactions in Natural Products and Medication
- Curcumin Nicotinate Selectively Induces Cancer Cell Apoptosis and Cycle Arrest through a P53-Mediated Mechanism
- Retrolective Studies on the Survival of Cancer Patients Treated With Mistletoe Extracts: A Meta-analysis
- Upon glycolytic suppression in multiple types of tumor cells, intracellular energy metabolism is reprogrammed toward mitochondrial OXPHOS in an autophagy-dependent manner to ensure cellular survival.
- Role of Plants in Stage IV Cancer
- Using the Heat-Shock Response To Discover Anticancer Compounds that Target Protein Homeostasis "Surprisingly, many of the strongly active compounds identified were natural products representing five diverse chemical classes (limonoids, curvularins, withanolides, celastraloids, and colletofragarones)"
- Neem components as potential agents for cancer prevention and treatment
- Anticancer and Cytotoxic Potential of Turmeric (Curcuma longa), Neem (Azadirachta indica), Tulasi (Ocimum sanctum) and Ginger (Zingiber officinale) Extracts on HeLa cell line
- Curcumin-Artesunate Based Polymeric Nanoparticle; Antiplasmodial and Toxicological Evaluation in Murine Model
- https://www.degruyter.com/view/journals/bmc/4/3/article-p287.xml?language=en
- Dying Cells Have Cellular 'Death Code'
- Peptides & Proteins
- Host defense peptides and peptidomimetics as new weapons for cancer treatment
- Synthetic and natural iron chelators: therapeutic potential and clinical use
- Natural Compound Histone Deacetylase Inhibitors (HDACi): Synergy with Inflammatory Signaling Pathway Modulators and Clinical Applications in Cancer
- Research Strategies in the Study of the Pro-Oxidant Nature of Polyphenol Nutraceuticals
- Inhibitors of DNA Methyltransferases From Natural Sources: A Computational Perspective
- Pathways in cancer - Homo sapiens (human)
- Metabilc Pathway
- The TNF Paradox in Cancer Progression and Immunotherapy
- Potential risks associated with traditional herbal medicine use in cancer care
- Lysine-carnitine conversion in normal and undernourished adult men-suggestion of a nonpeptidyl pathway
- Why the tumor cell metabolism is not that abnormal
- Understanding the synergy of cancer growth to advance care
- Niacin ameliorates oxidative stress, inflammation, proteinuria, and hypertension in rats with chronic renal failure
- The reverse Warburg effect is likely to be an Achilles' heel of cancer that can be exploited for cancer therapy
- The Effect of Zinc and Lysine Supplementation on Infection Rate and CD4 Count
- Raging the War Against Inflammation With Natural Products
- Ascorbic acid co-administration with artemisinin-based combination therapies in falciparum malaria
- Natural products as potent inhibitors of hypoxia-inducible factor-1Ξ± in cancer therapy
- HIF1A Employs CDK8-Mediator to Stimulate RNAPII Elongation in Response to Hypoxia
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