The anti-cancer properties of Piperlongumine.

Piperlongumine (also known as Piplartine)

Piperlongumine is an amide alkaloid constituent of the fruit of the long pepper plant (Piper longum). Piperlongumine has been found to have significant pharmacological relevance as an anticancer agent. It exhibits selective cytotoxicity against multiple cancer cells and inhibits cancer hallmarks, such as cell survival, proliferation, invasion, and metastasis.

Rodrigues, A.C.B.d.C., Silva, S.L.R., Dias, I.R.S.B. et al. Piplartine eliminates CD34 + AML stem/progenitor cells by inducing oxidative stress and suppressing NF-κB signalling. Cell Death Discov. 10, 147 (2024). https://doi.org/10.1038/s41420-024-01909-4

https://www.nature.com/articles/s41420-024-01909-4