The anti-cancer properties of Piperlongumine.

Piperlongumine and cancer

• Anticancer activity through its binding to the active sites of several cellular antioxidants (e.g. glutathione S transferase and carbonyl reductase) and ROS-induced oxidative stress.
• Ferroptosis
• STAT3 inhibitor
• HIF-1alpha  inhibitor

PL-directed anticancer agent by an electrophilicity-based prooxidant (ROS-generating agent) strategy 

References & Resources

• https://www.ncbi.nlm.nih.gov/pubmed/21753854?dopt=Abstract
• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5774503/
• https://www.ncbi.nlm.nih.gov/pubmed/28377224
• https://www.nature.com/articles/srep26357
• http://biofoundations.org/piperlongumine-from-long-pepper-selectively-kills-cancer-cells/
• https://www.sciencedirect.com/science/article/pii/S0753332218342999
• Piperlongumine suppresses hypoxia-induced HIF-1alpha expression in human gastric cancer cells. 
• Natural product piperlongumine inhibits the proliferation of oral squamous carcinoma cells by inducing ferroptosis and inhibiting intracellular antioxidant capacity {ref}
• Combination therapy with HSP90 inhibitors and piperlongumine promotes ROS-mediated ER stress in colon cancer cells {ref}