🔵 Visualizing A Synergistic Anticancer Network

Synergistic Network

Visualizing synergistic combinations for 10 main substances.

Network Legend

Main Substances

Highly Shared Synergistic

Moderately Shared Synergistic

Unique Synergistic

Highlighted Substance

Antagonistic Relationship

10

Main Substances

79

Synergistic Substances

189

Total Relationships

Network Insights

Core Cluster

ARTEMISININ, EGCG, CURCUMIN, HONOKIOL, and SHIKONIN form a tightly connected group via high-overlap compounds like Berberine and Quercetin.

Highly Connected

QUERCETIN and METFORMIN connect to 6 and 5 main substances respectively.

Peripheral Substances

GALLIC ACID and MAGNOLOL, both MAIN substances, have fewer synergies and appear farther from the central cluster.

Mebendazole

Mebendazole synergistically connects with 4 main substances: Artemisinin, Andrographolide, EGCG, and Honokiol.

Excel Spreadsheet

Studies for the synergistic combinations used in this visualization can be found in this Excel spreadsheet.

Antagonistic Relationship

Mebendazole blocked the anticancer activity of the diclofenac/disulfiram and metformin combinations, indicating an antagonistic interaction. This is visualized by a dashed red line between METFORMIN and MEBENDAZOLE. Source and Source

Synergistic Substance Network Visualization • Synergistic combinations identified in one or more cancer cell lines • Hover over nodes to see connections • For informational and research purposes only