Sulforaphane's cancer-inhibiting properties.

Sulforaphane is a naturally occurring compound in cruciferous vegetables like broccoli, Brussels sprouts, and cabbage. 

In laboratory studies, sulforaphane is a potent HDAC inhibitor that can reduce HDAC activity by up to 40%. It has also been shown to induce gene expression in regulating cancer cell growth and death. 

Sulforaphane blocks the translocalization of HIF-1α to the nucleus and suppresses hypoxia-mediated glycolysis.{ref}

Caution:  due to its direct binding to Keap1 sulforaphane produces potent and sustained activation of Nrf2 {ref} Sulforaphane's effects on NRF2-driven growth in cancer cells are complex and its potential benefits should be carefully considered in the context of specific cancer types and p53 status. 

Nrf2-active cancer cells are sensitive to glutamine depletion.

Sulforaphane may interfere with immunotherapy by immune checkpoint inhibitors (e.g., CTLA-4 antibodies and PD-1/PD-L1 antibodies) or CAR (chimeric antigen receptors) T-cells in cancer patients, and a combination of both treatments may not be advisable. {ref}

Intermittent and use in synergistic combinations may be most effective/safest e.g. 2 or 3x/week.

Vegetable	Sulforaphane Content (approx.)	Notes
Broccoli Sprouts	Very High	Highest known source of glucoraphanin; up to 100x more than mature broccoli.
Broccoli	High	Major source of glucoraphanin; best consumed raw or lightly steamed.
Kale	Moderate	Contains glucoraphanin; cooking reduces myrosinase activity.
Cauliflower	Moderate	Contains moderate levels of glucoraphanin; cooking reduces sulforaphane formation.
Cabbage	Low to Moderate	Has glucoraphanin and other glucosinolates; sulforaphane yield depends on preparation.
Brussels Sprouts	Low to Moderate	Contains glucoraphanin; cooking can significantly reduce sulforaphane formation.
Mustard Greens	Low	Contains other isothiocyanates, but lower in glucoraphanin compared to broccoli.
Turnips	Low	Contains small amounts of glucoraphanin; not a major source of sulforaphane.

Synergy

• + Selenium 10x
• + Zinc
• + Vitamin D
• + Curcumin
• + EGCg
• + Maitake
• + Dihydrocaffeic Acid
• + Eugenol
• + Aspirin
• + Curcumin + Aspirin
• + Apigenin
• Sulforaphane and myricetin act synergistically to induce apoptosis in 3T3‑L1 adipocytes {ref}
• + Inhibiting autophagy {ref}