The cancer-inhibiting properties of citric acid.

Citric acid occurs naturally in produce, such as citrus fruits, and may help to reduce the growth and spread of cancer cells by blocking the activity of certain enzymes involved in the cancer cell cycle.
  • glycolysis inhibitor {ref|ref}
  • activation of Apoptosis {ref}
  • kills tumor cells through activation of apical caspases {ref}
  • immune response
  • microbiome
  • citrate is converted to bicarbonate in the body
  • reduced concentration of citrate in cancer cells is an indicator of aggressiveness
  • enhances the bioavailability of minerals

Use pure citric acid, likely best from lemons (sour salt 100% citric acid). 

Approximately 99% of the world’s production of MCA is carried out using the fungus Aspergillus niger since 1919. Aspergillus niger is a known allergen. Citric acid was first isolated by William Scheele in England in 1784 from lemon juice. In 1917, American food chemist James Currie had begun experimenting with a process of making citric acid from mold. Currie discovered that strains of Aspergillus niger provided high yields of citric acid through a fermentation process using low-cost molasses as the raw material. This system was very cost-effective and rapidly adopted. Pfizer started to produce citric acid from Aspergillus niger in 1919, and this method is still used today across the world, particularly in China. The molecular formula of the natural citric acid obtained from lemons and limes and that of MCA is the same, C6H8O7. However, the potential presence of impurities or fragments from Aspergillus niger in MCA is a significant difference that may trigger deleterious effects when ingested. {ref}

Dr.Alberto Halabe's protocol: 2 to 10 grams/day (0.05 to 0.1g/kg/day) with water and with meals (in 3 or 4 divided doses). Citric acid is a chelating agent. As always, start with a low dose and up-titrate if you don't experience negative side effects.

In case you feel detox symptoms (shakiness, anxiety, nausea) due to citric acid, discontinue and do a gentle detox (some options: cilantro, chlorella, acerola, activated carbon with plenty of clean water, and modified citrus pectin) before resuming the therapy and try using 100% citric acid sour salt instead of manufactured citric acid to exclude any chance of an allergic reaction to Aspergillus niger.

Citric acid reduces ammonia


effect of citric acid supplementation on ammonia
Treatment of Hyperammonemia B. LEVIN, MD; ALEX RUSSELL, MD, MRCP 1967 https://jamanetwork.com/journals/jamapediatrics/article-abstract/502087


Effects of Citric Acid and l-Carnitine on Physical Fatigue
"These results suggest that citric acid reduces physiological stress and attenuates physical fatigue, whereas l-carnitine does not."

Citrate Promotes Excessive Lipid Biosynthesis and Senescence in Tumor Cells for Tumor Therapy {ref}

Obtaining citric acid crystals directly from lemons


Materials Needed:

Lemons
Water
Strainer
Large pot
Cheesecloth or fine mesh cloth
pH test strips (optional but helpful)
Baking soda (sodium bicarbonate)

Steps:

Gather organic lemons: 

Collect a significant number of lemons to yield a reasonable amount of citric acid. The citric acid content in lemons is relatively low, so you'll need quite a few.

Extract Citric Acid Solution:

Start by washing the lemons thoroughly to remove any dirt or contaminants.
Cut the lemons into small pieces, including the peel, pulp, and juice.
Place the lemon pieces in a large pot and add enough water to cover them.

Heat and Strain:

Bring the lemon-water mixture to a boil and then reduce the heat to a simmer.
Allow the mixture to simmer for an extended period, usually several hours, to extract the citric acid. After simmering, strain the liquid through a strainer lined with cheesecloth or a fine mesh cloth. This step will help remove the solid lemon particles.

Concentration:

Pour the strained liquid back into the pot and simmer it further to reduce the water content, concentrating the citric acid. The liquid will gradually thicken as water evaporates. Keep an eye on it and stir occasionally.

Crystallization:

Once the solution has reduced significantly, you can encourage crystallization by cooling the liquid. Place the pot in the refrigerator or a cool place. Over time, citric acid crystals might start to form as the concentrated solution cools.

Harvesting Crystals:

Once you see citric acid crystals forming, carefully collect them using a clean utensil. They might be attached to the sides or bottom of the container. Gently remove the crystals and let them air dry on a clean surface.

pH Testing (optional):

To ensure you've obtained citric acid crystals, you can use pH test strips. Citric acid is acidic, so testing the pH of your crystals should give you an acidic reading.

Neutralization (optional):

If you want to obtain a purer form of citric acid, you can perform a neutralization process. Dissolve the harvested citric acid crystals in a small amount of water and add baking soda (sodium bicarbonate) gradually until effervescence stops. This will react with citric acid, forming sodium citrate and carbon dioxide gas. Filter out the remaining solid to obtain sodium citrate, which can be converted back to citric acid through further processing.

Converting sodium citrate back to citric acid involves an acid-base reaction. Here's the process:

Conversion of Sodium Citrate to Citric Acid:

Sodium citrate can be converted back to citric acid by adding a strong acid to the sodium citrate solution. Hydrochloric acid (HCl) or sulfuric acid (H2SO4) are commonly used for this purpose. The reaction involves the displacement of the sodium ion with the hydrogen ion from the acid, resulting in the formation of citric acid and the corresponding sodium salt of the added acid:

Sodium Citrate + Acid → Citric Acid + Sodium Salt of Acid

After the reaction is complete, the resulting solution may need to be concentrated and then allowed to crystallize to obtain pure citric acid crystals. This can be achieved by evaporating the water from the solution under controlled conditions.

Crystallization of Citric Acid:

Once the citric acid solution is concentrated, it can be allowed to cool and crystallize. Controlling the cooling rate and providing suitable surfaces for crystal nucleation (such as seeding with a small amount of citric acid crystals) can result in the formation of larger, purer crystals.

Isolation and Drying:

The citric acid crystals are then separated from the remaining solution through filtration or centrifugation. The isolated crystals are typically washed with a small amount of chilled water to remove impurities and adhering solution. After washing, the crystals can be dried under controlled conditions to obtain the final purified citric acid product.

It's important to note that the conversion process requires careful control of the pH and reaction conditions to ensure the maximum yield and quality of the citric acid product. Additionally, working with strong acids requires appropriate safety measures and equipment to prevent harm.


References & Sources


Fundamentals of cancer metabolism

Glycolysis is less efficient than oxidative phosphorylation but cancer cells adapt to this disadvantage by increased glucose uptake.

Differences between citric C6H8O7 and ascorbic C6H8O6 acid



Nisin + Citric acid {study} as an antibiotic. Nisin inhibits the growth of Gram-negative bacteria when combined with membrane-disrupting chelators such as citric acid.


Rosmarinic Acid and Sodium Citrate Have a Synergistic Bacteriostatic Effect against Vibrio Species by Inhibiting Iron Uptake {study}

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