Danshen's cancer-suppressing properties.

Danshen, also called Salvia miltiorrhiza, is an herbaceous perennial plant belonging to the mint family (Lamiaceae). It is native to China, Japan and Korea and is widely used in Chinese, Japanese and Korean traditional medicine. The plant is known for its medicinal properties and is widely used for the treatment of a variety of diseases, including cancer. The main active ingredients of Salvia miltiorrhiza are danshensu, tanshinone IIA, and salvianolic acid B. 

The main active ingredients of Salvia miltiorrhiza, danshensu, tanshinone IIA and salvianolic acid B, have been shown to induce apoptosis in cancer cells by activating caspases, increasing p53 expression, and decreasing Bcl-2 expression. These compounds have also been shown to inhibit the proliferation of cancer cells by inducing cell cycle arrest at the G1/S phase.

The anticancer properties of Salvia miltiorrhiza are mediated by various pathways, such as the PI3K/Akt pathway, the mitogen-activated protein kinase (MAPK) pathway, and the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway.

TGF-β signaling inhibition {ref}

Ferroptosis {ref}

Synergy

• Panax Ginseng {study}
• Baicalein {study}
• Naringin