The cancer-fighting properties of Quercetin.

Quercetin belongs to a group of plant-based polyphenols known as flavonoids, responsible for many of the colors, flavors, and aromas of fruits, vegetables, and herbs. It is a potent antioxidant and has been found to scavenge free radicals, reduce inflammation, and inhibit the growth of cancer cells.

Quercetin has also been found to modulate multiple oncolytic pathways associated with cancer, including those involving the cell cycle, apoptosis, autophagy, angiogenesis, and metastasis.

Quercetin inhibits the uptake of lactic acid into tumor cells by suppressing the glycolytic enzymes hexokinase and phosphofructokinase. 

Antihyperammonemic effects {study}

Zinc ionophore {ref|study}

Iron chelator

Downregulation of miRNA-21 {ref}

Senolytic {ref}

Anticancer and apoptosis‑inducing effects of quercetin in vitro and in vivo

https://www.spandidos-publications.com/10.3892/or.2017.5766

Quercetin inhibits prostate cancer by attenuating cell survival and inhibiting anti-apoptotic pathways.

https://wjso.biomedcentral.com/articles/10.1186/s12957-018-1400-z

A review on pharmacological activities and synergistic effect of quercetin with small molecule agents

https://www.sciencedirect.com/science/article/abs/pii/S0944711321002798

The role of quercetin and vitamin c in NRF2-dependent oxidative stress production in breast cancer cells

https://www.researchgate.net/publication/312540960_The_role_of_quercetin_and_vitamin_c_in_NRF2-dependent_oxidative_stress_production_in_breast_cancer_cells

NRF2: inhibition at higher doses ( > 1,000 mg). Low to Moderate NRF2 activation at low dose.

From Nature to Clinic: Quercetin's Role in Breast Cancer Immunomodulation {review article}