The anticancer activity of Silibinin.

Silibinin is a flavanoid extracted from the milk thistle plant and is known to have anticancer activity.  The concentration of silibinin in milk thistle can vary depending on several factors, including the plant's growing conditions, the part of the plant used, and how the extract is processed.

However, most commercially available milk thistle supplements are standardized to contain between 70% and 80% silymarin Milk thistle. This means that for every gram of milk thistle extract in the supplement, there will be around 700-800 milligrams of silibinin.

• induction of proapoptotic molecules and inhibition of antiapoptotic molecules
• inhibition of Notch signaling {ref}
• downregulation of miRNA-21 {ref}
• inhibit LDH {ref}
• β-catenin inhibition
• NRF2 downregulation {ref}
• JAK2 inhibitor
• Please refer to the spreadsheet for more details on the effects of +100 supplements against +30 anticancer variables.

Synergy

+ Rutin

+ EGCG

+ Chrysin

+ I3C

+ Luteolin

+ Baicalein {ref}

+ HDAC inhibitors {ref}

Enhanced bioavailability with phosphatidylcholine {ref}

Role of Silymarin in Cancer Treatment: Facts, Hypotheses, and Questions {ref}

Kauntz, Henriette & Bousserouel, Souad & Gossé, Francine & Raul, Francis. (2013). Epigenetic effects of the natural flavonolignan silibinin on colon adenocarcinoma cells and their derived metastatic cells. Oncology letters. 5. 1273-1277. 10.3892/ol.2013.1190. 

Silibinin can enhance the bioavailability of Tamoxifen: https://ar.iiarjournals.org/content/30/1/79

References & Sources

• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2612997/
• https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/silibinin
• https://en.wikipedia.org/wiki/Silibinin
• http://ar.iiarjournals.org/content/34/8/4323.full