Astragalus: Traditional Immune Modulator
Ancient Chinese medicine meets modern cancer research in this powerful adaptogenic herb
Summary
- Immune System Modulation: Promotes T cell proliferation and enhances anti-tumor immunity
- Cancer Cell Inhibition: Induces apoptosis and growth inhibition through NF-κB downregulation
- Anti-Inflammatory: Reduces inflammation and scavenges free radicals
- Synergistic Effects: Works well with other traditional and modern therapies
Active Compounds & Mechanisms
Studies have shown that Astragalus's active compounds, including saponins, polysaccharides, and flavonoids, can modulate the immune system, inhibit cancer cell growth and metastasis, and induce apoptosis of cancer cells. The herb has also been found to reduce inflammation, scavenge free radicals, and modulate cell signaling pathways involved in tumorigenesis.
Astragalus Saponins (ASP)
Induce growth inhibition and apoptosis in human cancer cells by down-regulating NF-κB activity
Astragalus Polysaccharides (APS)
Promote T cell proliferation and enhance immune system function against tumors
Flavonoids
Provide antioxidant effects and modulate cellular pathways involved in cancer development
Immune System Modulation
Advanced Immunomodulatory Effects
Tumor Immune Function Enhancement: The immune function of the body is closely related to tumorigenesis. In tumor tissues, the number of Th1 cells decreases, and T cells' immune function is reduced. APS can promote T cells proliferation and induce Th1/Th2 to Th1 transition.
Dendritic Cell Maturation
APS induces DCs maturation and enhances the body's anti-tumor immune function
Regulatory T Cell Inhibition
APS can inhibit tumor production by reducing Treg numbers in the spleen
Multi-Cell Activation
Promotes activities of macrophages, NK cells, T lymphocytes, and B lymphocytes
Clinical Research Evidence
Advances on Immunoregulation Effect of Astragalus Polysaccharides
Comprehensive research on APS immunomodulatory effects shows significant potential for cancer therapy through immune system enhancement.
Synergist for Antitumor Therapy
"We reviewed the immunomodulatory effect of astragalus polysaccharides on macrophages, dendritic cells, natural killer cells, T lymphocytes, and B lymphocytes. We found that astragalus polysaccharides can promote the activities of macrophages, dendritic cells, natural killer cells, T lymphocytes, and B lymphocytes and induce the expression of various cytokines and chemokines."
Synergistic Combinations
Proven Therapeutic Partners
→ Vaccaria hispanica
→ Shiitake Mushroom
→ Salvia Miltiorrhiza
Traditional TCM combination
→ Pterostilbene
Modern polyphenol synergy
⚠️ Important Considerations
Hormonal Effects: Astragalus may increase estrogen levels. Consider this factor when choosing supplementation, especially for hormone-sensitive conditions.
Traditional Chinese Medicine Context
In Traditional Chinese Medicine, Astragalus (Huang Qi) is classified as a qi-tonifying herb, traditionally used to strengthen the spleen and lung qi, boost energy, and enhance immune function. Modern research validates many of these traditional uses, particularly its immune-enhancing and adaptogenic properties.
References & Scientific Literature
Immunoregulation Review:
Advances on immunoregulation effect of astragalus polysaccharides
Antitumor Synergy:
Synergist for antitumor therapy: Astragalus polysaccharides acting on immune microenvironment
Vaccaria Combination:
Mushroom Synergy:
Disclaimer: This information is for educational purposes only and should not replace professional medical advice. Always consult with healthcare providers before beginning any supplementation regimen, especially if you have hormone-sensitive conditions or are taking other medications.
Last updated: September 2025
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