Studies have shown that its active compounds, including saponins, polysaccharides, and flavonoids, can modulate the immune system, inhibit cancer cell growth and metastasis, and induce apoptosis of cancer cells.
Astragalus has also been found to reduce inflammation, scavenge free radicals, and modulate cell signaling pathways involved in tumorigenesis.
Astragalus saponins (ASP) induce growth inhibition and apoptosis in human cancer cells by down-regulating NF-κB activity.
Advances on immunoregulation effect of astragalus polysaccharides
"The immune function of the body is closely related to tumorigenesis (Zhang and Zhao, 2012). In tumor tissues, the number of Th1 cells decreases, and T cells’ immune function is reduced. APS can promote T cells proliferation and induce Th1/Th2 to Th1 transition. Moreover, APS can induce DCs maturation and enhance the body’s anti-tumor immune function (Bo et al., 2015; Jing et al., 2021). Regulatory cells (Treg) can suppress T cell activation and value-added, and APS can inhibit tumor production by reducing Treg numbers in the spleen"
Synergist for antitumor therapy: Astragalus polysaccharides acting on immune microenvironment
"We reviewed the immunomodulatory effect of astragalus polysaccharides on macrophages, dendritic cells, natural killer cells, T lymphocytes, and B lymphocytes. We found that astragalus polysaccharides can promote the activities of macrophages, dendritic cells, natural killer cells, T lymphocytes, and B lymphocytes and induce the expression of various cytokines and chemokines."
Synergy
→ Shiitake {ref}
→ Salvia Miltiorrhiza
→ Pterostilbene
>> increases estrogen levels
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