The cancer-suppressing properties of Grape Seed Extract.

All parts of grapes contain anti-cancer properties, including the seeds. Research shows that grape seedextract can prevent the growth of vascular epithelial growth factors in many cancers.

  • Grapeseed extract activates a protein called JNK which helps to regulate apoptosis.
  • Grapeseed extract inhibits cell proliferation by cell cycle arrest and apoptosis. 5
  • Grape seed extract and Green tea: mixtures of these extracts can synergistically enhance antioxidant activity. 6
  • Aromatase inhibitor (aromatase mainly converts androgens into estrogens).

Oligomeric proanthocyanidins (OPCs) target cancer stem-like cells and suppress tumor organoid formation in colorectal cancer {ref} 

Grape seed proanthocyanidin extract inhibits DNA and protein damage and labile iron, enzyme, and cancer cell activities

Grape Seed Procyanidins Inhibit the Growth of Breast Cancer MCF-7 Cells by Down-Regulating the EGFR/VEGF/MMP9 Pathway

ANTICANCER EFFECTS OF GRAPE SEED EXTRACT ON HUMAN CANCER: A REVIEW

References & Sources

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728696/
  2. http://www.prnewswire.com/news-releases/french-grape-seed-extract-vx1-found-effective-in-suppression-of-cancer-pathway-300263659.html
  3. http://www.mc.uky.edu/Toxicology/News-Grape%20seed%20extract.pdf
  4. http://www.sciencedirect.com/science/article/pii/S1756464615005186
  5. http://www.europeanreview.org/wp/wp-content/uploads/3282-3291-Induction-of-cell-cycle-arrest-and-apoptosis-by-grape-seed-procyanidin-extract-in-human-bladder-cancer-BIU87.pdf
  6. http://www.notulaebotanicae.ro/index.php/nbha/article/view/10358

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