The anticancer activity of Lycopene.

Lycopene is a carotenoid that has been extensively studied for its potential anti-cancer properties. Lycopene is found in several fruits and vegetables, including tomatoes, watermelons, apricots, and pink grapefruits. It is a powerful antioxidant and has been found to act as an anti-inflammatory agent.

• induces the anti-proliferation of HGC-27 cells
• lycopene supplementation decreases the expression of STAT3 by inducing the protein inhibitor of activated STAT3 expression in ovarian tissues {study}
• antitumor activity of lycopene in HNSCC cells
• FAK downregulation

Top 10 Foods Highest in Lycopene

Synergy

• vitamin D3
• broccoli (sulforaphane)
• S-allylcysteine {study}
• (aspirin)

 

Antagonism

• iron-rich foods {article}

References & Sources

• https://newsatjama.jama.com/2012/12/06/study-finds-lycopene-most-effective-carotenoid-in-reducing-breast-cancer-risk-2/
• INHIBITORY EFFECT OF LYCOPENE AGAINST THE GROWTH OF HUMAN GASTRIC CANCER CELL
• STAT3 as a target for anti-cancer therapy
• Role of STAT3 in Cancer Metastasis and Translational Advances
• Lycopene Improves Insulin Sensitivity through Inhibition of STAT3/Srebp-1c-Mediated Lipid Accumulation and Inflammation in Mice fed a High-Fat Diet.
• Lycopene inhibits the cell proliferation and invasion of human head and neck squamous cell carcinoma