Shikonin's anti-cancer properties.

Shikonin is a naphthoquinone pigment isolated from the traditional Chinese herbal medicine comfrey root.

Shikonin Inhibits Cancer Through P21 Upregulation and Apoptosis Induction {ref}

Shikonin and 4-hydroxytamoxifen synergistically inhibit the proliferation of breast cancer cells through activating apoptosis signaling pathway in vitro and in vivo {ref}

Shikonin Inhibits Tumor Growth in Mice by Suppressing Pyruvate Kinase M2-mediated Aerobic Glycolysis {ref}

Shikonin Inhibits Thyroid Cancer Cell Growth and Invasiveness Through Targeting Major Signaling Pathways {ref}

Shikonin inhibits the Warburg effect, cell proliferation, invasion and migration by downregulating PFKFB2 expression in lung cancer {ref}

Enhancement of NK cells proliferation and function by Shikonin {ref}

Ferroptosis

Half-life 8-9 hours {ref}

Synergy

Melatonin sensitizes shikonin-induced cancer cell death mediated by oxidative stress via inhibition of the SIRT3/SOD2-AKT pathway {ref}