The anticancer activity of Honokiol and Magnolol.

Magnolia Bark contains the powerful natural compounds honokiol {article} and magnolol {review/review/article/article}. 


Honokiol acts against cancer cells in several ways: as an inhibitor of angiogenesis, and also as a Targeted Agent blocking the VEGFR2 receptor on cancer cells.

Structural similarity to estrogen might be acting as agonist.

Honokiol also sensitizes cancer cells for chemotherapy.

Honokiol inhibits STAT3.

Honokiol induces ferroptosis

Honokiol Decreases Lung Cancer Metastasis through Inhibition of the STAT3 Signaling Pathway

Honokiol-enhanced cytotoxic T lymphocyte activity against cholangiocarcinoma cells mediated by dendritic cells pulsed with damage-associated molecular patterns  {ref}

Magnolol treatment significantly suppressed  NSCLC tumor growth in a mouse xenograft model in vivo.{study}

Magnolol inhibits growth and induces apoptosis in esophagus cancer KYSE-150 cell lines via the MAP kinase pathway {study}.

Autophagic inhibition with liposomal honokiol {study}

Magnolol inhibits the expression of HIF-1α, VEGF, CD31.

Magnolol decreases Bcl-2 (negative regulator of cell death, preventing cells from undergoing apoptosis) protein expression.

"In Vivo Synergistic Antitumor Activity of Magnolol and Honokiol Combination in a Glioblastoma Mouse Model". This study evaluated the efficacy of a combination of magnolol and honokiol (MH) compared to Temozolomide (TMZ) in a mouse model of glioblastoma. The results revealed that MH was superior to TMZ in terms of tumor growth inhibition and survival rate. MH treatment resulted in significantly higher levels of apoptosis, decreased infiltration of macrophages and T cells, and increased numbers of natural killer cells. Additionally, MH treatment inhibited tumor angiogenesis and reduced the expression of vascular endothelial growth factor and its receptor in the tumor. These results suggest that the combination of magnolol and honokiol may be an effective treatment for glioblastoma.
Magnolol and honokiol exert a synergistic anti-tumor effect through autophagy and apoptosis in human glioblastomas (xenograft mouse model, intraperitoneal injection of 20 mg/kg/day for 14 days) - Yu-Chen Cheng, Dueng-Yuan Hueng, Hua-Yin Huang, Jang-Yi Chen, and Ying Chen. In this study, the Hono-Mag combination is superior to standard GBM treatment with the chemotherapeutic agentTemozolomide (TMZ).

Synergy

  • Honokiol + Magnolol (see image above) Dosage: titrate, example 3:1, 2:1, 1:1
  • Honokiol → Modified Citrus Pectin {article}
  • → Chloroquine {study}
  • Magnolia Bark →  Ginger 
  • Autophagy/mitophagy inhibitors + Magnolol {study}
  • Magnolol → Berberine (anti-inflammatory)

Antagonism

  • Magnolol + piperine {ref}

Products

Magnolol


To improve absorption I'd take magnolol and honokiol with some coconut oil, and away from other supplements. Because of the sedating effect, I would take it at night.

Half-life 1-2 hours

Suggested therapeutic dosage: 0.5 - 3 grams of Honokiol per day and in divided doses, for at least 14 days cycles. Magnolol: titrate 4:1, 3:1, 2:1, 1:1 e.g 1 gr Honokiol with 0.25 gr Magnolol (4:1)


Cautionsedating effect


References & Sources


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