Magnolia Bark contains the powerful natural compounds honokiol {article} and magnolol {review/review/article/article}.
Honokiol acts against cancer cells in several ways: as an inhibitor of angiogenesis, and also as a Targeted Agent blocking the VEGFR2 receptor on cancer cells.
Structural similarity to estrogen might be acting as agonist.
Honokiol also sensitizes cancer cells for chemotherapy.
Honokiol also sensitizes cancer cells for chemotherapy.
Honokiol inhibits STAT3.
Honokiol induces ferroptosis
Honokiol Decreases Lung Cancer Metastasis through Inhibition of the STAT3 Signaling Pathway
Honokiol-enhanced cytotoxic T lymphocyte activity against cholangiocarcinoma cells mediated by dendritic cells pulsed with damage-associated molecular patterns {ref}
Magnolol treatment significantly suppressed NSCLC tumor growth in a mouse xenograft model in vivo.{study}
Magnolol inhibits growth and induces apoptosis in esophagus cancer KYSE-150 cell lines via the MAP kinase pathway {study}.
Autophagic inhibition with liposomal honokiol {study}
Magnolol inhibits the expression of HIF-1α, VEGF, CD31.
Magnolol decreases Bcl-2 (negative regulator of cell death, preventing cells from undergoing apoptosis) protein expression.
"In Vivo Synergistic Antitumor Activity of Magnolol and Honokiol Combination in a Glioblastoma Mouse Model". This study evaluated the efficacy of a combination of magnolol and honokiol (MH) compared to Temozolomide (TMZ) in a mouse model of glioblastoma. The results revealed that MH was superior to TMZ in terms of tumor growth inhibition and survival rate. MH treatment resulted in significantly higher levels of apoptosis, decreased infiltration of macrophages and T cells, and increased numbers of natural killer cells. Additionally, MH treatment inhibited tumor angiogenesis and reduced the expression of vascular endothelial growth factor and its receptor in the tumor. These results suggest that the combination of magnolol and honokiol may be an effective treatment for glioblastoma.
Synergy
- Honokiol + Magnolol (see image above) Dosage: titrate, example 3:1, 2:1, 1:1
- Honokiol → Modified Citrus Pectin {article}
- → Chloroquine {study}
- Magnolia Bark → Ginger
- Autophagy/mitophagy inhibitors + Magnolol {study}
- Magnolol → Berberine (anti-inflammatory)
Antagonism
- Magnolol + piperine {ref}
Products
Magnolol
- Magnolol https://liftmode.com/magnolol-powder/#10g (Ships from the USA)
- https://www.chemfaces.com/natural/Magnolol-CFN98872.html
To improve absorption I'd take magnolol and honokiol with some coconut oil, and away from other supplements. Because of the sedating effect, I would take it at night.
Half-life 1-2 hours
Suggested therapeutic dosage: 0.5 - 3 grams of Honokiol per day and in divided doses, for at least 14 days cycles. Magnolol: titrate 4:1, 3:1, 2:1, 1:1 e.g 1 gr Honokiol with 0.25 gr Magnolol (4:1)
⚠ Caution: sedating effect
References & Sources
- Magnolol and honokiol exert a synergistic anti-tumor effect through autophagy and apoptosis in human glioblastomas
- Effects of magnolol treatment on UVB induced skin tumors in SKH-1 mice.
- Magnolol inhibits growth and induces apoptosis in esophagus cancer KYSE-150 cell lines via the MAP kinase pathway
- "In Vivo Synergistic Antitumor Activity of Magnolol and Honokiol Combination in a Glioblastoma Mouse Model". PLoS ONE, 8(9): e75050, 2013. https://doi.org/10.1371/journal.pone.0075050
- Magnolol Triggers Caspase-Mediated Apoptotic Cell Death in Human Oral Cancer Cells through JNK1/2 and p38 Pathways {ref}
- Studies on inhibitors of skin tumor promotion, IX. Neolignans from Magnolia officinalis
- Honokiol induces apoptosis and autophagy via the ROS/ERK1/2 signaling pathway in human osteosarcoma cells in vitro and in vivo
- Magnolol Inhibits the Growth of Non-Small Cell Lung Cancer via Inhibiting Microtubule Polymerization
- Magnolol Suppresses Metastasis via Inhibition of Invasion, Migration, and Matrix Metalloproteinase-2/-9 Activities in PC-3 Human Prostate Carcinoma Cells {ref}
- https://www.wddty.com/magazine/2017/june/the-herb-that-kills-cancer-1.html
- Honokiol induces apoptosis and autophagy via the ROS/ERK1/2 signaling pathway in human osteosarcoma cells in vitro and in vivo
- Intravenous Honokiol in Drug-Resistant Cancer: Two Case Reports
- https://www.humannaturenaturalhealth.com/sites/default/files/IOS/Honokiol_Reference.pdf
- https://advancedrejuvenationinstitute.com/cancer/6-lysis-ablation/cancer-research-artemisinin-artesunate.html
- honokiol Thu, Jul 24, 2008 – A50 · The San Francisco Examiner (San Francisco, California) · Newspapers.com
- Honokiol nanomicellar formulation produced increased oral bioavailability and anticancer effects in triple negative breast cancer (TNBC) {ref}
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