Sodium bicarbonate, also known as baking soda, is a crystalline salt made up of sodium and bicarbonate ions. Potassium bicarbonate can substitute for sodium bicarbonate to reduce sodium intake.
Bicarbonate HCO3 and Cancer
- Alkalization therapy: bicarbonate is naturally alkaline, with a pH of 8
- Bicarbonate can act as a buffering agent, which helps to reduce the acidity of the environment around the tumor cells.
- Increase CO2 in tissues
Article: Baking soda may treat cancer
- Effects of Alkalization Therapy on Chemotherapy Outcomes in Metastatic or Recurrent Pancreatic Cancer:
Twenty-eight patients with metastatic or recurrent pancreatic cancer were assessed in this study. Alkalization therapy consisted of an alkaline diet with supplementary oral sodium bicarbonate (3.0-5.0 g/day). Results: The mean urine pH was significantly higher after the alkalization therapy (6.85±0.74 vs. 6.39±0.92; p<0.05). The median overall survival from the start of alkalization therapy of the patients with high urine pH (>7.0) was significantly longer than those with low urine pH (≤ 7.0) (16.1 vs. 4.7 months; p<0.05). link to study
" Here, we show that oral NaHCO(3) selectively increased the pH of tumors and reduced the formation of spontaneous metastases in mouse models of metastatic breast cancer. This treatment regimen was shown to significantly increase the extracellular pH, but not the intracellular pH, of tumors by (31)P magnetic resonance spectroscopy and the export of acid from growing tumors by fluorescence microscopy of tumors grown in window chambers. NaHCO(3) therapy also reduced the rate of lymph node involvement, yet did not affect the levels of circulating tumor cells, suggesting that reduced organ metastases were not due to increased intravasation. In contrast, NaHCO(3) therapy significantly reduced the formation of hepatic metastases following intrasplenic injection, suggesting that it did inhibit extravasation and colonization. "
- Bicarbonate has also been shown to increase the effectiveness of radiation therapy and to reduce side effects.
A case report: GL is a 79 year old man followed in the GU clinic at the Moffitt Cancer Center. He presented with hematuria in January 2004 and was found to have a large right renal cancer with clot extending into the inferior vena cava (stage T3b, N2, Mx). He underwent a nephrectomy with clot removal at the Moffitt Cancer Center in February, 2004. In June, 2005, he developed metastatic disease in his liver. He was treated with Sutent, but the tumor progressed with metastases developing in the subcutaneous tissues and retroperitoneal lymph nodes. He was unable to tolerate ALT-801. In September 2007 he elected to discontinue all conventional therapy and began a self-administered regimen of vitamins, supplements, and 3 “heaping tablespoons” of sodium bicarbonate in water per day (about 40 grams total). As of the date of this submission, he has maintained this therapy with no complications. His weight is stable. He walks 2 miles every day and had cataract surgery in March 2008 without complications. CT scans from Dec 5, 2007 and April 18, 2008 are shown in figure S3. These images are representative in that some of the liver lesions have increased in size, some have decreased, and some have remained stable. Interestingly, the tumors that were necrotic in the initial scan became much less so on the follow-up study. At the time of this submission (2009) the patient remains clinically well. {ref, see Supplementary Materials}.
International Society of Sports Nutrition position stand: sodium bicarbonate and exercise performance {ref}
"For single-dose supplementation protocols, 0.2 g/kg of sodium bicarbonate seems to be the minimum dose required to experience improvements in exercise performance. The optimal dose of sodium bicarbonate dose for ergogenic effects seems to be 0.3 g/kg. Higher doses (e.g., 0.4 or 0.5 g/kg) may not be required in single-dose supplementation protocols, because they do not provide additional benefits (compared with 0.3 g/kg) and are associated with a higher incidence and severity of adverse side-effects. 5. For single-dose supplementation protocols, the recommended timing of sodium bicarbonate ingestion is between 60 and 180 min before exercise or competition. 6. Multiple-day protocols of sodium bicarbonate supplementation can be effective in improving exercise performance. The duration of these protocols is generally between 3 and 7 days before the exercise test, and a total sodium bicarbonate dose of 0.4 or 0.5 g/kg per day produces ergogenic effects. The total daily dose is commonly divided into smaller doses, ingested at multiple points throughout the day (e.g., 0.1 to 0.2 g/kg of sodium bicarbonate consumed at breakfast, lunch, and dinner). The benefit of multiple-day protocols is that they could help reduce the risk of sodium bicarbonate-induced side-effects on the day of competition. 7. Long-term use of sodium bicarbonate (e.g., before every exercise training session) may enhance training adaptations, such as increased time to fatigue and power output. 8. The most common side-effects of sodium bicarbonate supplementation are bloating, nausea, vomiting, and abdominal pain. The incidence and severity of side-effects vary between and within individuals, but it is generally low. Nonetheless, these side-effects following sodium bicarbonate supplementation may negatively impact exercise performance. Ingesting sodium bicarbonate (i) in smaller doses (e.g., 0.2 g/kg or 0.3 g/kg), (ii) around 180 min before exercise or adjusting the timing according to individual responses to side-effects, (iii) alongside a high-carbohydrate meal, and (iv) in enteric-coated capsules are possible strategies to minimize the likelihood and severity of these side-effects. 9. Combining sodium bicarbonate with creatine or beta-alanine may produce additive effects on exercise performance."
Caution: Sodium bicarbonate taken in amounts that exceed the capacity of the kidneys to get rid of excess sodium may cause metabolic alkalosis. Do not exceed the maximum recommended dosage.
NaCl (Salt) → % Na (Sodium) = 39.3 %
NaHCO3 (Sodium Bicarbonate) → % Na (Sodium) = 27.4 %
1000mg or 1 gram of Salt contains 393mg Sodium.
1000mg of 1 gram of Sodium Bicarbonate contains 274mg of Sodium.
4 grams of Sodium Bicarbonate contain 1094mg of Sodium.
The Daily Value for sodium is less than 2,300 milligrams (mg) per day.
Americans eat on average about 3,400 mg of sodium per day.
According to the American Heart Association (AHA), the minimum physiological requirement for sodium is less than 500 mg a day.
References and Sources
- http://drsircus.com/cancer/cancer-studies-ph-medicine/
- Baking soda can help immunotherapy drugs to fight difficult-to-treat tumors.
- Bicarbonate Increases Tumor pH and Inhibits Spontaneous Metastases {study}
- https://www.ncbi.nlm.nih.gov/pubmed/30004244
- Extended Use of Sodium Bicarbonate in Patients With Cancer {pilot phase I trial}
- Safety and Tolerability of Long-Term Sodium Bicarbonate Consumption in Cancer Care {review}
- An Old Remedy for influenza, and flu.
- Bicarbonate Increases Tumor pH and Inhibits Spontaneous Metastases
- Citrate helps to prevent calcium deposits in the kidney. Sodium (found in sodium bicarbonate, sodium citrate or other sodium salts) can increase calcium levels in the blood and urine.
- Does Baking Soda Function as a Magic Bullet for Patients With Cancer? A Mini Review
- Carbon Dioxide Transport and Carbonic Anhydrase in Blood and Muscle
- http://www.kf-kopp.de/wissenschaftliche-arbeiten/the-bicarbonate-deficiency-syndrome-bds/
- The Potential Role of Systemic Buffers in Reducing Intratumoral Extracellular pH and Acid-Mediated Invasion
- https://www.news-medical.net/news/20220129/Research-uncovers-how-lactic-acid-disrupts-the-bodys-defense-against-tumors.aspx
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