https://www.nature.com/articles/s41467-023-38594-3
" At a clinically relevant dose, alanine supplementation synergizes with OXPHOS inhibition or conventional chemotherapy eliciting marked antitumor activity in patient-derived xenografts. Our findings reveal multiple druggable vulnerabilities of SMARCA4/2-loss exploiting a GLUT1/SLC38A2-mediated metabolic shift. Particularly, unlike dietary deprivation approaches, alanine supplementation can be readily applied to current regimens for better treatment of these aggressive cancers."
Inhibition of glutamine synthesis induces glutamate dehydrogenase-dependent ammonia fixation into alanine in co-cultures of astrocytes and neurons
https://www.sciencedirect.com/science/article/abs/pii/S019701861100101X
Alanine is suggested as an important ammonia-scavenging molecule.
T-cell activation depends on extracellular alanine
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934407/
.jpeg)
.png)
No comments:
Post a Comment