Leukemia: natural substances and drug repurposing

Artemisinin {ref | ref}

Butyrate {ref}

Artemisinin + Butyrate "A combination of low concentrations of sodium butyrate (1 mM) and DHA (20 ÌM) kills all leukemia cells in culture within 24 hours, suggesting that the combination of short chain fatty acids and artemisinin or its analogs may be an effective treatment for cancers" {ref}

Magnolol {ref}

Ellagic acid + Quercetin {ref}

Ceproheptadine {ref}

Hesperidin {ref}

I3C {ref}

Niacin "Improvement of niacin status in rats significantly decreased nitrosourea-induced leukemia incidence. The data from our rat model suggest that niacin supplementation of cancer patients may decrease the severity of short- and long-term side effects of chemotherapy, and could improve tumor cell killing through activation of poly(ADP-ribose)-dependent apoptosis pathways."{ref}

Nettle tea {ref}

Curcumin/Cannabidiol/Quercetin {ref}

Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction {ref}

d-Limonene {ref|ref}

Plasma ammonia in patients with acute leukemia.{ref}

Formononetin and Dihydroartemisinin Act Synergistically to Induce Apoptosis in Human Acute Myeloid Leukemia Cell Lines {ref}

Metformin and Thymoquinone Synergistically Inhibit Proliferation of Imatinib-Resistant Human Leukemic Cells {ref}

Antitumor effects of sodium selenite on acute lymphocytic leukemia {case report}

Vitamin B6, leukemia’s deadly addiction {ref} "Zhang cautions that his research on how cancer cells use the B6 vitamin to proliferate does not mean that cancer patients would necessarily benefit from reduced intake of B6 vitamin as part of their diet. The B6 vitamin is necessary for the survival of healthy cells. Zhang’s research shows that cancer cells take advantage of the PDXK enzyme to increase B6 vitamin activity. This increased activity fuels AML growth."

SEARCH STRINGS

leukemia

acute lymphoblastic leukemia (ALL)

acute myeloid leukemia (AML)

chronic lymphocytic leukemia (CLL)

chronic myeloid leukemia (CML)

natural substances leukemia treatment (Bing / Google  / Consensus / PubMed / ScienceDirect)

natural substances leukemia treatment synergy (Bing / Google  / Consensus / PubMed / ScienceDirect)

Artemisinin + leukemia (Bing / Google  / Consensus / PubMed / ScienceDirect)

Honokiol + leukemia

Orlistat + leukemia

Aspirin + leukemia

Modified Citrus Pectin + leukemia

Ursolic acid + leukemia

Luteolin + leukemia

Magnolol + leukemia

Piperine + leukemia

Celecoxib + leukemia

Indole-3-Carbinol + leukemia

Melatonin + leukemia

Curcumin + leukemia

Berberine + leukemia

Graviola + leukemia

Ellagic acid + leukemia

Quercetin + leukemia  {ref | ref | ref | ref | ref | ref

Butyrate + leukemia {ref | ref | ref | ref | ref

Vitamin D + leukemia {ref | ref | ref | ref |

Vitamin K2 + leukemia 

EGCG + leukemia

Aloe Vera + leukemia

Allicin + leukemia

Ginger + leukemia

6-Shogaol + leukemia

Anthocyanin + leukemia

Curcumin + leukemia

Emodin + leukemia

Apigenin + leukemia

Salvia miltiorrhiza + leukemia

Astragalus + leukemia

Garcinol + leukemia                                                                      

DHA docosahexaenoic acid + leukemia

Citric acid + leukemia

Andrographis + leukemia

D-limonene + leukemia

Salvia miltiorrhiza + leukemia

Shikonin + leukemia                     

Boswellia + leukemia   

Grapeseed extract + leukemia

Phellinus linteus + leukemia

Naringin + leukemia       

IP6 + leukemia

Inositol + leukemia

Pterostilbene + leukemia

Licoric + leukemia

Boswellia + leukemia

Chlorogenic acid + leukemia

Theobromine + leukemia

Lipoic acid + leukemia

Hydroxycitrate + leukemia

methylene blue + leukemia

Milk Thistle + leukemia

Baicalein + leukemia

Salvia miltiorrhiza + leukemia

Nigella Sativa + leukemia

Thymoquinone + leukemia

Lycopene + leukemia

Sulforaphane + leukemia

Dihydrocaffeic Acid + leukemia 

Vitamin C + leukemia   

Phosphatidylcholine + leukemia

Magnesium + leukemia

Vitamin B6 + leukemia

Juglone + leukemia

Riboflavin + leukemia

Ashwagandha + leukemia

Bicarbonate + leukemia    

Piperlongumine + leukemia

Sanguinarine + leukemia

Berberine + leukemia

Caffeine + leukemia

Galangal + leukemia

Tulsi + leukemia

Piper nigrum + leukemia

Oligomeric proanthocyanidins + leukemia

Taurine + leukemia

AHCC + leukemia

Fucoidan + leukemia

Carnosic acid + leukemia

Fisetin + leukemia

Caffeic acid + leukemia

Mistletoe + leukemia

Chaga + leukemia

Rosmarinic acid + leukemia {ref}

Cinnamon + leukemia

Subversion of Systemic Glucose Metabolism As a Mechanism to Support the Growth of Leukemia Cells "Restoration of normal glucose regulation may be a feasible strategy to suppress systemic growth of malignant cell types."

https://ashpublications.org/blood/article/132/Supplement%201/908/265974/Subversion-of-Systemic-Glucose-Metabolism-As-a

References

https://aacrjournals.org/cancerdiscovery/article/11/2/500/3265/The-Hepatic-Microenvironment-Uniquely-Protects