Ursolic acid
Ursolic acid inhibits the growth of human pancreatic cancer and enhances the antitumor potential of gemcitabine in an orthotopic mouse model through suppression of the inflammatory microenvironment
https://pubmed.ncbi.nlm.nih.gov/26909608/
Ursolic acid inhibits growth and induces apoptosis in gemcitabine-resistant human pancreatic cancer via the JNK and PI3K/Akt/NF-κB pathways
https://www.spandidos-publications.com/10.3892/or.2012.1827
Ursolic acid promotes apoptosis, autophagy, and chemosensitivity in gemcitabine-resistant human pancreatic cancer cells
https://onlinelibrary.wiley.com/doi/10.1002/ptr.6669
Ursolic acid restores sensitivity to gemcitabine through the RAGE/NF-κB/MDR1 axis in pancreatic cancer cells and in a mouse xenograft model
https://www.jfda-online.com/journal/vol29/iss2/6/
Ursolic acid induces apoptosis in pancreatic cancer cells associated with inhibition of STAT3 and down-regulation of Bcl-XL
Magnolol
Magnolol Suppresses Pancreatic Cancer Development In Vivo and In Vitro via Negatively Regulating TGF-β/Smad Signaling
https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2020.597672/full
Mebendazole
Mebendazole disrupts stromal desmoplasia and tumorigenesis in two models of pancreatic cancer
https://www.oncotarget.com/article/28014/
Aspirin + Metformin
Transcriptomic analysis of pancreatic cancer cells in response to metformin and aspirin: an implication of synergy
https://www.nature.com/articles/srep13390
Fisetin
Fisetin inhibits the proliferation, migration and invasion of pancreatic cancer by targeting PI3K/AKT/mTOR signaling
Naringin
Naringenin decreases invasiveness and metastasis by inhibiting TGF-β-induced epithelial to mesenchymal transition in pancreatic cancer cells
Xanthohumol
Xanthohumol inhibits angiogenesis by suppressing nuclear factor-κB activation in pancreatic cancer
Danshen
Exploration of Dan-Shen-Yin against pancreatic cancer based on network pharmacology combined with molecular docking and experimental validation
https://www.sciencedirect.com/science/article/pii/S2590262824000546
Berberine
Functional inhibition of lactate dehydrogenase suppresses pancreatic adenocarcinoma progression
Integrative Management of Pancreatic Cancer (PDAC): Emerging Complementary Agents and Modalities {review}
Nrf2 Activation Sensitizes K-Ras Mutant Pancreatic Cancer Cells to Glutaminase Inhibition {studystudy}
Activating an Estrogen Receptor Can Stop Pancreatic Cancer Cells from Growing {article}
"Activating the G protein-coupled estrogen receptor (GPER) – a receptor found on the surface of many normal and cancer tissues – has been shown to stop pancreatic cancer from growing, but may also make tumors more visible to the immune system and thus more susceptible to modern immunotherapy. "
https://www.researchgate.net/publication/355046135_Honokiol_Suppresses_Perineural_Invasion_of_Pancreatic_Cancer_by_Inhibiting_SMAD23_Signaling
https://www.researchgate.net/publication/342606456_Honokiol_Suppressed_Pancreatic_Cancer_Progression_via_miR-101Mcl-1_Axis
https://www.researchgate.net/publication/307939430_Honokiol_Suppresses_Pancreatic_Tumor_Growth_Metastasis_and_Desmoplasia_by_Interfering_with_Tumor-Stromal_Cross-Talk
https://www.researchgate.net/publication/355046135_Honokiol_Suppresses_Perineural_Invasion_of_Pancreatic_Cancer_by_Inhibiting_SMAD23_Signaling/fulltext/615b082aa6fae644fbd40630/Honokiol-Suppresses-Perineural-Invasion-of-Pancreatic-Cancer-by-Inhibiting-SMAD2-3-Signaling.pdf
https://www.researchgate.net/figure/Effects-of-Honokiol-on-the-cell-viabilities-of-pancreatic-cancer-cells-A-PANC-1-and_fig1_342606456
https://www.researchgate.net/publication/342606456_Honokiol_Suppressed_Pancreatic_Cancer_Progression_via_miR-101Mcl-1_Axis/fulltext/5efcc5234585155050813ecc/Honokiol-Suppressed-Pancreatic-Cancer-Progression-via-miR-101-Mcl-1-Axis.pdf
https://www.researchgate.net/figure/Honokiol-induces-apoptosis-in-human-pancreatic-cancer-cells-MiaPaCa-and-Panc1-cells-were_fig9_51458998
https://www.researchgate.net/publication/320853746_Orlistat_Reduces_Proliferation_and_Enhances_Apoptosis_in_Human_Pancreatic_Cancer_Cells_PANC-1
https://www.researchgate.net/figure/Effect-of-cancer-and-treatment-with-rutin-and-orlistat-on-caspase-activity-in-a-MCF-7_fig4_329110201
https://www.researchgate.net/publication/370918582_Orlistat_Induces_Ferroptosis_in_Pancreatic_Neuroendocrine_Tumors_by_Inactivating_the_MAPK_Pathway
https://pubmed.ncbi.nlm.nih.gov/37283794/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10240670/
https://pubmed.ncbi.nlm.nih.gov/29061815/
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https://www.researchgate.net/publication/347590051_Can_aspirin_use_reduce_the_risk_of_pancreatic_cancer_an_updated_systematic_review_and_meta-analysis
https://www.researchgate.net/publication/338058009_Aspirin_use_and_pancreatic_cancer_risk_A_systematic_review_of_observational_studies
https://www.researchgate.net/publication/348260295_Effects_of_aspirin_on_pancreatic_cancer_cells_PANC-1_and_its_potential_molecular_mechanism
https://www.mdanderson.org/publications/focused-on-health/low-dose-aspirin-cancer-prevention.h20-1589046.html
https://www.webmd.com/cancer/news/20140806/daily-aspirin-may-help-prevent-cancer-study-shows
https://www.justanswer.com/medical/2ys3l-aspirin-pancreatitis-pain.html
https://www.empr.com/home/news/do-nsaids-statins-reduce-pancreatic-cancer-risk/
https://www.researchgate.net/publication/253337475_Aspirin_A_Potential_Therapeutic_Approach_in_Pancreatic_Cancer
https://www.researchgate.net/publication/311779592_Aspirin_Use_and_Reduced_Risk_of_Pancreatic_Cancer
https://www.researchgate.net/figure/The-efficacy-of-combination-of-varying-amounts-of-orlistat-with-compound-1-orlistat_fig1_276541698
https://www.researchgate.net/publication/289118825_A_new_approach_to_metastatic_cancer_prevention_Modified_Citrus_Pectin_MCP_a_unique_pectin_that_blocks_cell_surface_lectins
https://www.researchgate.net/publication/26513143_Clinical_Benefit_in_Patients_with_Advanced_Solid_Tumors_Treated_with_Modified_Citrus_Pectin_A_Prospective_Pilot_Study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893732/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657392/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576403/
https://www.researchgate.net/publication/295911275_Ursolic_acid_inhibits_the_growth_of_human_pancreatic_cancer_and_enhances_the_antitumor_potential_of_gemcitabine_in_an_orthotopic_mouse_model_through_suppression_of_the_inflammatory_microenvironment
https://www.researchgate.net/figure/Ursolic-acid-UA-inhibits-pancreatic-cancer-cell-growth-and-proliferation-and-enhances_fig1_295911275
https://www.researchgate.net/publication/340002838_Ursolic_acid_promotes_apoptosis_autophagy_and_chemosensitivity_in_gemcitabine-resistant_human_pancreatic_cancer_cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785537/
https://www.researchgate.net/publication/225069245_Ursolic_acid_inhibits_growth_and_induces_apoptosis_in_gemcitabine-resistant_human_pancreatic_cancer_via_the_JNK_and_PI3KAktNF-kB_pathways
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914350/
https://www.researchgate.net/publication/230836894_Synthesis_of_novel_ursolic_acid_heterocyclic_derivatives_with_improved_abilities_of_antiproliferation_and_induction_of_p53_p21waf1_and_NOXA_in_pancreatic_cancer_cells
https://www.researchgate.net/publication/349682078_DPYD_down-regulated_by_the_potentially_chemopreventive_agent_luteolin_interacts_with_STAT3_in_pancreatic_cancer
https://www.researchgate.net/publication/283493015_Luteolin_decreases_invasiveness_deactivates_STAT3_signaling_and_reverses_interleukin-6_induced_epithelial-mesenchymal_transition_and_matrix_metalloproteinase_secretion_of_pancreatic_cancer_cells
https://www.researchgate.net/publication/324611192_Dietary_compound_luteolin_inhibits_pancreatic_cancer_growth_by_targeting_BCL-2
https://www.researchgate.net/publication/370858642_Multi-Faceted_Role_of_Luteolin_in_Cancer_Metastasis_EMT_Angiogenesis_ECM_Degradation_and_Apoptosis
https://www.researchgate.net/publication/265859433_Luteolin_and_Gemcitabine_Protect_Against_Pancreatic_Cancer_in_an_Orthotopic_Mouse_Model
https://link.springer.com/article/10.1007/s12032-021-01508-8
https://journals.sagepub.com/doi/10.1177/1934578X221133579
https://www.researchgate.net/publication/355425949_Delivery_of_Ursolic_Acid_by_Polyhydroxybutyrate_Nanoparticles_for_Cancer_Therapy_in_silico_and_in_vitro_Studies
https://www.researchgate.net/publication/295998522_Blockade_of_the_epidermal_growth_factor_receptor_tyrosine_kinase_activity_by_quercetin_and_luteolin_leads_to_growth_inhibition_and_apoptosis_of_pancreatic_tumor_cells
https://www.researchgate.net/publication/347302828_Magnolol_Suppresses_Pancreatic_Cancer_Development_In_Vivo_and_In_Vitro_via_Negatively_Regulating_TGF-bSmad_Signaling
https://www.researchgate.net/publication/364031277_Magnolol_as_a_Potential_Anticancer_Agent_A_Proposed_Mechanistic_Insight
https://www.researchgate.net/publication/347302828_Magnolol_Suppresses_Pancreatic_Cancer_Development_In_Vivo_and_In_Vitro_via_Negatively_Regulating_TGF-bSmad_Signaling/fulltext/600e6db6299bf14088bc6af0/Magnolol-Suppresses-Pancreatic-Cancer-Development-In-Vivo-and-In-Vitro-via-Negatively-Regulating-TGF-b-Smad-Signaling.pdf
https://www.researchgate.net/publication/320731714_Magnolol_inhibits_tumor_cell_growth_in_human_pancreatic_cancer_cell
https://www.researchgate.net/publication/51851224_Magnolol_a_natural_compound_induces_apoptosis_of_SGC-7901_human_gastric_adenocarcinoma_cells_via_the_mitochondrial_and_PI3KAkt_signaling_pathways
https://www.frontiersin.org/articles/10.3389/fonc.2020.597672/full
https://www.researchgate.net/figure/Magnolol-MAG-inhibits-pancreatic-orthotopic-xenograft-growth-in-a-mouse-model-A_fig1_347302828
https://www.researchgate.net/publication/356569838_In_Vitro_Inhibition_of_Piper_nigrum_and_Piperine_on_Growth_Migration_and_Invasion_of_PANC-1_Human_Pancreatic_Cancer_Cells
https://www.researchgate.net/publication/366822399_Pharmacological_Approaches_A_Review_of_Piperine_Anticancer_Activities_in_Oral_Cancer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818432/
https://www.frontiersin.org/articles/10.3389/fphar.2021.772418/full
https://www.researchgate.net/publication/356572411_Piperine-Loaded_PLGA_Nanoparticles_as_Cancer_Drug_Carriers
https://www.researchgate.net/publication/362318897_Piperine_Alleviates_Acute_Pancreatitis_a_possible_role_for_FAM134B_and_CCPG1_Dependent_ER-phagy
https://www.researchgate.net/publication/356569838_In_Vitro_Inhibition_of_Piper_nigrum_and_Piperine_on_Growth_Migration_and_Invasion_of_PANC-1_Human_Pancreatic_Cancer_Cells/fulltext/61a1877c3068c54fa520443a/In-Vitro-Inhibition-of-Piper-nigrum-and-Piperine-on-Growth-Migration-and-Invasion-of-PANC-1-Human-Pancreatic-Cancer-Cells.pdf
https://www.researchgate.net/publication/317186298_Piperine_as_a_Potential_Anti-cancer_Agent_A_Review_on_Preclinical_Studies
https://www.researchgate.net/publication/312034352_Piperine_and_Its_Various_Physicochemical_and_Biological_Aspects_A_Review
https://www.researchgate.net/publication/346165426_Synthesis_and_evaluation_of_new_compounds_bearing_3-4-aminopiperidin-1-ylmethyl_magnolol_scaffold_as_anticancer_agents_for_the_treatment_of_non-small_cell_lung_cancer_via_targeting_autophagy
https://www.researchgate.net/publication/323209302_Celecoxib_suppresses_proliferation_and_metastasis_of_pancreatic_cancer_cells_by_down-regulating_STAT3_NF-kB_and_L1CAM_activities
https://www.researchgate.net/publication/328575459_A_case_of_advanced_pancreatic_cancer_with_remarkable_response_to_thalidomide_celecoxib_and_gemcitabine
https://www.researchgate.net/publication/47679491_Effects_of_Capecitabine_and_Celecoxib_in_Experimental_Pancreatic_Cancer
https://www.researchgate.net/publication/343182801_Celecoxib_combined_with_salirasib_strongly_inhibits_pancreatic_cancer_cells_in_2D_and_3D_cultures
https://www.researchgate.net/publication/6628493_Assessment_of_celecoxib_pharmacodynamics_in_pancreatic_cancer
https://www.researchgate.net/publication/8046314_GemcitabineIrinotecancelecoxib_in_pancreatic_cancer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378654/
https://www.researchgate.net/publication/345368363_Indole-3-carbinol_as_potential_factor_in_anticarcinogenic_protection_nutritionist%27s_position
https://www.researchgate.net/publication/275604076_Abstract_2556_Indole-3-carbinol_I3C_and_gemcitabine_as_potential_combinatorial_therapy_in_pancreatic_cancer
https://addon.life/2021/07/06/indole-3-carbinol-benefits-cancer/
https://www.mskcc.org/cancer-care/integrative-medicine/herbs/indole-3-carbinol
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989150/
https://www.researchgate.net/publication/323460396_Combined_treatment_of_gemcitabine_with_indole-3-carbinol_or_metformin_on_drug_efficacy_in_pancreatic_cancer_cell_lines_The_role_of_human_equilibrative_nucleoside_transporters
https://www.researchgate.net/publication/323460396_Combined_treatment_of_gemcitabine_with_indole-3-carbinol_or_metformin_on_drug_efficacy_in_pancreatic_cancer_cell_lines_The_role_of_human_equilibrative_nucleoside_transporters/fulltext/5a9753bfaca27214056b3fe9/Combined-treatment-of-gemcitabine-with-indole-3-carbinol-or-metformin-on-drug-efficacy-in-pancreatic-cancer-cell-lines-The-role-of-human-equilibrative-nucleoside-transporters.pdf
https://cancerci.biomedcentral.com/articles/10.1186/s12935-023-03031-4
https://www.researchgate.net/profile/Xiangguo-Liu-2
https://www.researchgate.net/publication/327760442_Melatonin_and_pancreatic_cancer_Current_knowledge_and_future_perspectives
https://www.researchgate.net/publication/368229745_Pancreatic_melatonin_enhances_anti-tumor_immunity_in_pancreatic_adenocarcinoma_through_regulating_tumor-associated_neutrophils_infiltration_and_NETosis
https://www.researchgate.net/publication/353388654_Pan-cancer_analyses_reveal_genomics_and_clinical_characteristics_of_the_melatonergic_regulators_in_cancer
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454927/
https://www.researchgate.net/publication/280114500_Curcumin_and_Pancreatic_Cancer_A_Research_and_Clinical_Update
https://www.researchgate.net/publication/305354364_Curcumin_AntiCancer_Studies_in_Pancreatic_Cancer
https://www.researchgate.net/publication/339759145_Curcumin_and_pancreatic_cancer_Phase_II_clinical_trial_experience
https://www.webmd.com/cancer/can-turmeric-fight-cancer
https://www.mskcc.org/cancer-care/integrative-medicine/herbs/nigella-sativa
https://www.researchgate.net/publication/294104632_Curcumin_A_Natural_Multitarget_Treatment_for_Pancreatic_Cancer
https://www.researchgate.net/publication/340741285_Curcumin_Combination_Chemotherapy_in_Pancreatic_Cancer
https://www.researchgate.net/publication/327727722_Curcumin_analogs_Their_roles_in_pancreatic_cancer_growth_and_metastasis
https://www.researchgate.net/publication/366068449_Effects_of_Berberine_against_Pancreatitis_and_Pancreatic_Cancer
https://www.researchgate.net/publication/343122080_Cell_Metabolomics_Reveals_Berberine-Inhibited_Pancreatic_Cancer_Cell_Viability_and_Metastasis_by_Regulating_Citrate_Metabolism
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9738201/
https://www.researchgate.net/publication/349865741_Berberine_inhibits_the_proliferation_of_pancreatic_cancer_targeting_pancreatic_cancer_stem_cells
https://www.researchgate.net/publication/359923211_Berberine_inhibits_the_proliferation_of_pancreatic_cancer_cells_by_targeting_pancreatic_cancer_stem_cells_through_regulating_EMT_signaling_pathway
https://www.researchgate.net/publication/44585189_Berberine_Inhibits_Cell_Growth_and_Mediates_Caspase-Independent_Cell_Death_in_Human_Pancreatic_Cancer_Cells
https://www.medicalnewstoday.com/articles/319720#:~:text=A%202012%20study%20found%20graviola%20may%20be%20beneficial,should%20not%20use%20it%20as%20a%20primary%20treatment.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888937/
https://www.researchgate.net/publication/290448944_Graviola_A_Systematic_Review_on_Its_Anticancer_Properties
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091294/
https://www.researchgate.net/figure/Effect-of-Graviola-extract-on-pancreatic-cancer-cell-viability-A-MTT-cytotoxicity_fig1_222710316
https://www.researchgate.net/publication/222710316_Graviola_A_Novel_Promising_Natural-Derived_Drug_That_Inhibits_Tumorigenicity_and_Metastasis_of_Pancreatic_Cancer_Cells_In_Vitro_and_In_Vivo_Through_Altering_Cell_Metabolism
https://www.researchgate.net/figure/Effect-of-Graviola-extract-on-the-metabolism-of-pancreatic-cancer-cells-A-Western-blot_fig2_222710316
https://www.researchgate.net/publication/348876794_Determining_the_effect_of_ellagic_acid_on_the_proliferation_and_migration_of_pancreatic_cancer_cell_lines
https://www.researchgate.net/figure/Ellagic-acid-inhibits-pancreatic-cancer-cell-proliferation-A-PANC-1-B-AsPC-1-C_fig1_348876794
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https://www.researchgate.net/publication/5256479_Ellagic_acid_induces_apoptosis_through_inhibition_of_nuclear_factor_kappa_B_in_pancreatic_cancer_cells
https://www.researchgate.net/publication/312933419_Ellagic_acid_inhibits_the_proliferation_of_human_pancreatic_carcinoma_PANC-1_cells_in_vitro_and_in_vivo/fulltext/58a37773a6fdcc05f1658309/Ellagic-acid-inhibits-the-proliferation-of-human-pancreatic-carcinoma-PANC-1-cells-in-vitro-and-in-vivo.pdf
https://www.researchgate.net/publication/312933419_Ellagic_acid_inhibits_the_proliferation_of_human_pancreatic_carcinoma_PANC-1_cells_in_vitro_and_in_vivo
https://www.researchgate.net/publication/355898244_Quercetin_Impact_in_Pancreatic_Cancer_An_Overview_on_Its_Therapeutic_Effects
https://www.researchgate.net/publication/364082684_Quercetin_improves_pancreatic_cancer_chemo-sensitivity_by_regulating_oxidative-inflammatory_networks
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580629/
https://www.researchgate.net/publication/281141391_Quercetin_Mediates_b-Catenin_in_Pancreatic_Cancer_Stem-Like_Cells
https://www.researchgate.net/publication/271656485_The_Flavonoid_Quercetin_Inhibits_Pancreatic_Cancer_Growth_In_Vitro_and_In_Vivo
https://www.researchgate.net/figure/Studies-on-the-therapeutic-effects-of-quercetin-in-pancreatic-cancer_tbl1_359761959
https://pubmed.ncbi.nlm.nih.gov/36181395/
https://www.researchgate.net/publication/342162581_Phenolic_compound_ellagic_acid_inhibits_mitochondrial_respiration_and_tumor_growth_in_lung_cancer
https://www.researchgate.net/figure/Quercetin-may-sensitize-pancreatic-cancer-to-chemotherapeutic-agents-by-regulating_fig1_364082684
https://www.researchgate.net/publication/360825701_Butyrate_a_postbiotic_of_intestinal_bacteria_affects_pancreatic_cancer_and_gemcitabine_response_in_in_vitro_and_in_vivo_models
https://www.researchgate.net/publication/271580021_Butyrate_inhibits_pancreatic_cancer_invasion
https://www.researchgate.net/publication/7652123_Sodium_butyrate_sensitise_human_pancreatic_cancer_cells_to_both_the_intrinsic_and_the_extrinsic_apoptotic_pathways
https://www.researchgate.net/publication/9030349_Butyrate_inhibits_pancreatic_cancer_invasion
https://www.researchgate.net/publication/360919133_Butyrate_a_Postbiotic_of_Intestinal_Bacteria_Affects_Pancreatic_Cancer_and_Gemcitabine_Response_in_In_Vitro_and_In_Vivo_Models
https://www.researchgate.net/publication/371224492_Clostridium_butyricum_and_its_metabolite_butyrate_promote_ferroptosis_susceptibility_in_pancreatic_ductal_adenocarcinoma
https://pubmed.ncbi.nlm.nih.gov/35617803/
https://www.researchgate.net/publication/5346422_Vitamin_D_and_Pancreatic_Cancer
https://www.researchgate.net/publication/258429397_Vitamin_D_and_Pancreatic_Cancer-An_Update
https://www.researchgate.net/publication/281054876_Vitamin_D_and_pancreatic_cancer
https://pubmed.ncbi.nlm.nih.gov/26276715/
https://pubmed.ncbi.nlm.nih.gov/18504144/
https://www.researchgate.net/publication/276356800_Vitamin_D_and_pancreatic_cancer_A_pooled_analysis_from_the_Pancreatic_Cancer_Case-Control_Consortium
https://www.researchgate.net/publication/49792103_Role_of_Vitamin_D_in_the_Prevention_of_Pancreatic_Cancer
https://www.researchgate.net/publication/348295028_The_role_of_butyrate_in_surgical_and_oncological_outcomes_in_colorectal_cancer
https://www.researchgate.net/publication/351364523_Dietary_Vitamin_K_Intake_and_the_Risk_of_Pancreatic_Cancer_A_Prospective_Study_of_101695_American_Adults
https://www.researchgate.net/publication/40023384_Naturally_occurring_K_vitamins_inhibit_pancreatic_cancer_cell_survival_through_a_caspase-dependent_pathway
https://pubmed.ncbi.nlm.nih.gov/33949658/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958717/
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