Paeoniflorin

Paeoniflorin, a monoterpene glycoside derived from the roots of Paeonia lactiflora (peony), exhibits promising anticancer activity through multiple mechanisms. It inhibits tumor cell proliferation, induces apoptosis, and suppresses metastasis and angiogenesis in various cancers, including breast, lung, liver, and colorectal cancers. Paeoniflorin modulates key signaling pathways such as PI3K/Akt, MAPK, and NF-κB, which are critical in cancer progression. It also enhances chemosensitivity, reduces inflammation, and exerts antioxidant effects, contributing to its therapeutic potential. Studies, primarily preclinical, show low toxicity and synergistic effects with chemotherapeutic agents, making it a candidate for adjunct cancer therapy.