- low dose may have more potent antitumor effects than high dose resveratrol {study}
Caution: Patients with hormone-sensitive cancers should exercise caution with resveratrol, as concentrations between 3 and 10 μM—comparable to those required for its other biological effects—can exhibit estrogen-like properties. These concentrations may activate transcription through both estrogen and androgen receptors, potentially leading to the stimulation of cancer cell proliferation. {ref}
Reaching 3 to 10 μM concentrations in the blood would typically require > 300mg doses from supplements (can vary based on individual metabolism).
Please refer to the spreadsheet for more details on resveratrol's effects against over 25 anticancer variables.
References
- (2017) Resveratrol reverses the Warburg effect by targeting the pyruvate dehydrogenase complex in colon cancer cells
- (2016) Resveratrol Inhibits Ovarian Tumor Growth in an In Vivo Mouse Model
- (2015) Resveratrol’s Low-Dose Anticancer Effect
- Resveratrol Induces Growth Inhibition, S-phase Arrest, Apoptosis, and Changes in Biomarker Expression in Several Human Cancer Cell Lines
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