SLC4A11 mediates ammonia import and promotes cancer stemness in hepatocellular carcinoma

In a study published two days ago, researchers discovered that ammonia enters cells via the SLC4A11 transporter and acts as a nitrogen source for the biosynthesis of amino acids and nucleotides.

Elevated ammonia levels enhanced cancer stem cell properties in vitro and promoted tumor initiation in vivo. Enhancing ammonia clearance reduced the stemness of hepatocellular carcinoma (HCC) cells and slowed tumor growth. Higher serum ammonia levels were associated with an increased risk of developing HCC.