Pain Management

Cancer-related pain can be managed with a combination of pharmacologic and non-pharmacologic approaches. Commonly used pharmacologic approaches include opioids, non-steroidal anti-inflammatory drugs, antidepressants, anticonvulsants, and local anesthetics.

Combining Alternative, Synergistic and Adjuvant Therapies for Optimal Care

Aspirin 

• + DHA(docosahexaenoic acid) {ref / ref}
• 🔶 drug information

White willow bark 

• 240 mg/day. nonselective inhibitor of COX-1 and COX-2 used to block inflammatory prostaglandins.

Boswellia 

• studies have found that it may help reduce pain in patients with cancer.
• can inhibit the leukotriene biosynthesis in neutrophilic granulocytes by inhibiting 5-LOX, thus affecting various inflammatory diseases that are perpetuated by leukotrienes. 300-500 mg two or three times/day

Luteolin {ref}

Magnesium-L-threonate {ref}

Palmitoylethanolamide 

Methylene Blue 🛈 {ref}

Diaphragmatic breathing

• also known as deep breathing, it has a major influence on relaxing the muscles which tense up as a result of pain and in turn further aggravate the pain itself. {ref}

Acupuncture

Cyproheptadine

• blocks the action of serotonin. Although not a first-line pain therapeutic, cyproheptadine may represent a pain management option for refractory headaches and relief of symptoms acerbated by chronic pain such as insomnia and cachexia. {ref}
• 🔶 drug information

Ursolic acid (UA)

• efficient COX-2 inhibitor. 6 mg/kg body weight was able to inhibit neointima formation in rats’ carotid arteries.
• protective effect of UA on the human umbilical vein endothelial cells (HUVECs) damaged by C-reactive protein. 
• of note, UA is capable to make platelets more susceptible to aggregation

Ellagic acid (EA)

•  a major constituent of pomegranate juice induces antinociceptive and anti-inflammatory effects.

Thymoquinone

• beneficial for decreasing neuropathic pain

Pycnogenol

•  inhibits TNF-α–induced NF-kB activation

Cat’s claw

• prevents the activation of the transcriptional factor NF-kB and it directly inhibits TNF-α production by up to 65-85%.

Curcumin

• inhibit inflammation by suppressing NF-kB, restricting various activators of NF-kB as well as stemming its expression.
• + Metformin {ref}

Rosmarinus officinalis

Cannabidiolic acid (CBDA)

Dong quai

RHUS Toxicodendron D6

Palmitoylethanolamide (PEA)

Lycopene

Celecoxib

• 🔶 drug information
• + B vitamins {ref}

Acetazolamide

• 🔶 drug information
• {Ref}

Naproxen

• + Tramadol {ref} 1:1
• 🔶 drug information Tramadol may cause serious or life-threatening breathing problems, especially during the first 24 to 72 hours of treatment and any time dose is increased. Tell your doctor if you have or have ever had slowed breathing or asthma. Take the smallest dose of tramadol that works, and take it for the shortest possible time.
• 🔶 drug information Naproxen. 
• do not take aspirin, naproxen, or ibuprofen within 8-12 hours of each other

Co-Crystal Celecoxib and Tramadol Combination (CTC)

• {ref}
• 🔶 drug information 

Ashwagandha + Curcumin + Boswellia + Zinc

Honokiol

California poppy

β-Caryophyllene + Paracetamol {study}

Anti-emetic therapy: ginger with lemon, peppermint, ceylon cinnamon, and cbd oil

Hair loss prevention

• Cooling Caps