Lipoic acid (LA), also known as α-lipoic acid, alpha-lipoic acid (ALA) and thioctic acid, is an organosulfur compound derived from caprylic acid (octanoic acid). ALA is made in animals normally and is essential for aerobic metabolism. {ref} Alpha lipoic acid helps to increase the efficiency of the Krebs cycle by acting as a co-enzyme, which helps to facilitate the transfer of electrons between molecules. This helps to speed up the cycle, allowing the body to produce more energy. Alpha lipoic acid also helps to reduce oxidative damage caused by free radicals, which can lead to cell damage and disease. Additionally, alpha lipoic acid helps to recycle other important antioxidants such as vitamins C and E, which helps to maintain a healthy balance of antioxidants in the body.
- inhibits cell proliferation of tumor cells in vitro and in vivo
- immunomodulatory effects on both adaptive and innate immune systems {ref}
- autophagy inhibition {ref}
Supplements
- RS-ALA/THIOCTIC ACID
- Sources of caprylic acid: MCT oil, coconut oil, palm oil
As always, start low at a very low dose and up-titrate if no adverse effects. The Andy Cutler Chelation Study Group
Alpha-lipoic acid might slow blood clotting. Taking alpha-lipoic acid along with medications that also slow blood clotting might increase the risk of bruising and bleeding.
Synergy
- → Hydroxycitrate {ref}
- Curcumin + Lipoic acid; may help with neuropathy {ref} protective against liver injury {ref}
- → Methylene Blue 🛈 to reduce lactic acid {ref}
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