Boswellia's cancer-suppressing properties.




Boswellia (also known as Indian frankincense, Salai guggul or Shallaki in Ayurvedic medicine) is a genus of trees in the Burseraceae family native to the dry regions of India, northern Africa, and the Arabian Peninsula. 

The anticancer effects of Boswellia are thought to be mediated by several mechanisms. These include inhibition of nuclear factor kappa-B (NF-kB) signaling, induction of apoptosis via caspase activation, and suppression of cellular proliferation, angiogenesis, and metastasis. The active ingredients in Boswellia extracts responsible for these effects are largely terpenoids, such as boswellic acid and acetyl-boswellic acid. These compounds are believed to interfere with the activity and expression of a variety of proteins and enzymes, including NF-kB and cyclooxygenase-2, which play a role in tumor growth and metastasis.
 
In addition, Boswellia extracts have been shown to block the epidermal growth factor receptor (EGFR)/PI3K/AKT signaling pathway, which is important for tumor cell survival and growth. Furthermore, they have been found to reduce the expression of vascular endothelial growth factor (VEGF), an important regulator of angiogenesis. Boswellia extracts may reduce the expression of matrix metalloproteinase-2 (MMP-2), which is involved in tumor metastasis


Synergy

Caution

Boswellic acid formulations are NOT suitable for treatment of pediatric high-grade glioma due to tumor-promoting potential {study}

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